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Colloids at Fluid Interfaces
Open AccessFeature PaperArticle

Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers

1
Departamento de Química Física, Facultad de Ciencias Químicas, Universidad Complutense de Madrid. Ciudad Universitaria s/n, 28040 Madrid, Spain
2
Instituto Pluridisciplinar, Universidad Complutense de Madrid. Paseo Juan XXIII, 1, 28040 Madrid, Spain
3
Departamento de Química Física, Facultad de Ciencias Químicas, Universidad de Salamanca. Plaza Caídos s/n, 37008 Salamanca, Spain
4
Institut Laue-Langevin. 71 Avenue des Martyrs, CS 20156, 38042 Grenoble, France
*
Author to whom correspondence should be addressed.
Processes 2020, 8(1), 94; https://doi.org/10.3390/pr8010094
Received: 23 December 2019 / Revised: 31 December 2019 / Accepted: 8 January 2020 / Published: 10 January 2020
(This article belongs to the Special Issue Particle-Laden Fluid Interfaces: Dynamics and Interfacial Rheology)
Carbon nanomaterials are widespread in the atmospheric aerosol as a result of the combustion processes and their extensive industrial use. This has raised many question about the potential toxicity associated with the inhalation of such nanoparticles, and its incorporation into the lung surfactant layer. In order to shed light on the main physical bases underlying the incorporation of carbon nanomaterials into lung surfactant layers, this work has studied the interaction at the water/vapor interface of carbon nanosheets (CN) with Langmuir monolayers of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC), with this lipid being the main component of lung surfactant layers and responsible of some of the most relevant features of such film. The incorporation of CN into DPPC Langmuir monolayers modifies the lateral organization of the DPPC at the interface, which is explained on the basis of two different effects: (i) particles occupy part of the interfacial area, and (ii) impoverishment of the lipid composition of the interface due to lipid adsorption onto the CN surface. This results in a worsening of the mechanical performance of the monolayers which may present a negative impact in the physiological performance of lung surfactant. It would be expected that the results obtained here can be useful as a step toward the understanding of the most fundamental physico-chemical bases associated with the effect of inhaled particles in the respiratory cycle. View Full-Text
Keywords: particles; lipids; Langmuir monolayer; lung surfactant; pollution; dilational rheology; toxicity; carbon nanosheets particles; lipids; Langmuir monolayer; lung surfactant; pollution; dilational rheology; toxicity; carbon nanosheets
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Muñoz-López, R.; Guzmán, E.; Velázquez, M.M.; Fernández-Peña, L.; Merchán, M.D.; Maestro, A.; Ortega, F.; G. Rubio, R. Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers. Processes 2020, 8, 94.

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