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Article

Study of the Lamellar and Micellar Phases of Pluronic F127: A Molecular Dynamics Approach

1
Facultad de Ciencias Exactas y Naturales, Departamento de Física, Universidad de Buenos Aires, Buenos Aires 1428, Argentina
2
Instituto de Física de Buenos Aires (IFIBA), CONICET—Universidad de Buenos Aires, Buenos Aires 1428, Argentina
3
Department of Biomedical Informatics, University of Utah, 421 Wakara Way, Suite 140, Salt Lake City, UT 84108, USA
*
Author to whom correspondence should be addressed.
Processes 2019, 7(9), 606; https://doi.org/10.3390/pr7090606
Received: 21 August 2019 / Revised: 3 September 2019 / Accepted: 5 September 2019 / Published: 7 September 2019
(This article belongs to the Special Issue Molecular Dynamics Modeling and Simulation)
In this work, we analyzed the behavior of Pluronic F127 through molecular dynamics simulations at the coarse-grain level, focusing on the micellar and lamellar phases. To this aim, two initial polymer conformations were considered, S-shape and U-shape, for both simulated phases. Through the simulations, we were able to examine the structural and mechanical properties that are difficult to access through experiments. Since no transition between S and U shapes was observed in our simulations, we inferred that all single co-polymers had memory of their initial configuration. Nevertheless, most copolymers had a more complex amorphous structure, where hydrophilic beads were part of the lamellar-like core. Finally, an overall comparison of the micellar a lamellar phases showed that the lamellar thickness was in the same order of magnitude as the micelle diameter (approx. 30 nm). Therefore, high micelle concentration could lead to lamellar formation. With this new information, we could understand lamellae as orderly packed micelles. View Full-Text
Keywords: Pluronic F127; poloxamer; molecular dynamics; lamellar; micellar Pluronic F127; poloxamer; molecular dynamics; lamellar; micellar
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MDPI and ACS Style

Albano, J.M.R.; Grillo, D.; Facelli, J.C.; Ferraro, M.B.; Pickholz, M. Study of the Lamellar and Micellar Phases of Pluronic F127: A Molecular Dynamics Approach. Processes 2019, 7, 606. https://doi.org/10.3390/pr7090606

AMA Style

Albano JMR, Grillo D, Facelli JC, Ferraro MB, Pickholz M. Study of the Lamellar and Micellar Phases of Pluronic F127: A Molecular Dynamics Approach. Processes. 2019; 7(9):606. https://doi.org/10.3390/pr7090606

Chicago/Turabian Style

Albano, Juan M.R., Damian Grillo, Julio C. Facelli, Marta B. Ferraro, and Mónica Pickholz. 2019. "Study of the Lamellar and Micellar Phases of Pluronic F127: A Molecular Dynamics Approach" Processes 7, no. 9: 606. https://doi.org/10.3390/pr7090606

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