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Processes 2019, 7(2), 90; https://doi.org/10.3390/pr7020090

Evaluation of Conditions Affecting Properties of Gac (Momordica Cocochinensis Spreng) Oil-Loaded Solid Lipid Nanoparticles (SLNs) Synthesized Using High-Speed Homogenization Process

1
Department of Chemical Engineering and Processing, Nong Lam University, Ho Chi Minh City 700000, Vietnam
2
Department of Chemical Engineering, HCMC University of Technology, VNU-HCM, Ho Chi Minh City 700000, Vietnam
3
NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam
4
Center of Excellence for Biochemistry and Natural Products, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam
*
Authors to whom correspondence should be addressed.
Received: 4 January 2019 / Revised: 2 February 2019 / Accepted: 3 February 2019 / Published: 12 February 2019
(This article belongs to the Special Issue Green Separation and Extraction Processes)
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Abstract

In this study, we attempted the preparation of gac oil-loaded solid lipid nanoparticles (SLNs) by the high-speed homogenization method using Naterol SE solid lipid, a cosmetic self-emulsifying base, and surfactant and investigated the effects of different conditions on the characteristics of the resulting nanoparticles. The suspensions containing 5% active agents (gac-oil, w/w) were dispersed in a surfactant concentration of 5% (w/w) (Span 80:Tween 80 ratio of 28:72 w/w) and 2.5% (w/w) of solid lipid (Naterol SE) concentration. Suitable conditions for hot homogenization were 13,000 rpm, 60 min and 60 °C for speed, time and temperature, respectively. The suitable conditions for the subsequent cold homogenization were 25 min of homogenization time and 5 °C of temperature. The results showed that the mean size of SLNs-gac oil was 107 nm (measured by laser diffraction spectrometry, LDS), and dried size of SLNs-gac oil ranged from 50 to 80 nm (measured by transmission electron microscope, TEM). In addition, the study investigated the impact of gac oil content on the particle size of SLNs-gac oil and its stability under different storage conditions of UV radiation and storage temperature. At high storage temperatures, the color changes (ΔE) of the samples were more profound in comparison to that at the low storage temperature. The ΔE value of the blank sample (SLN-FREE gac-oil) was higher than that of the Gac oil-loaded SLNs samples (SLN-gac oil). View Full-Text
Keywords: Solid lipid nanoparticles (SLNs); Momordica cocochinensis Spreng; gac oil; hot homogenization; cold homogenization; Naterol SE; carotenoids Solid lipid nanoparticles (SLNs); Momordica cocochinensis Spreng; gac oil; hot homogenization; cold homogenization; Naterol SE; carotenoids
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Mai, H.C.; Nguyen, T.S.V.; Le, T.H.N.; Nguyen, D.C.; Bach, L.G. Evaluation of Conditions Affecting Properties of Gac (Momordica Cocochinensis Spreng) Oil-Loaded Solid Lipid Nanoparticles (SLNs) Synthesized Using High-Speed Homogenization Process. Processes 2019, 7, 90.

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