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Article

A Mechanistic Model of Mass Transfer in the Extraction of Bioactive Compounds from Intact Sorghum Pericarp

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Department of Chemical Engineering, Faculty of Engineering, Universitas Gadjah Mada, Jl. Grafika No. 2, Yogyakarta 55281, Indonesia
2
Department of Agricultural & Biosystems Engineering, Faculty of Agricultural Technology, Universitas Gadjah Mada, Jl. Flora No. 1, Yogyakarta 55281, Indonesia
*
Author to whom correspondence should be addressed.
Processes 2019, 7(11), 837; https://doi.org/10.3390/pr7110837
Received: 14 October 2019 / Revised: 26 October 2019 / Accepted: 28 October 2019 / Published: 9 November 2019
(This article belongs to the Section Process Control and Supervision)
The extraction of phytochemical compounds from intact red sorghum grains was developed as an alternative process for producing bioactive material in the pharmaceutical industry. A mechanistic model is needed to better understand the process and enable predictive simulations for designing commercial-scale extraction systems. This paper presents a mathematical model for predicting phytochemical concentrations in the solvent and inside the pericarp of the grain at different positions during the extraction. The model is based on the mass transfer mechanism from inside the pericarp to its solid surface by diffusion, and then from the surface to a solvent during the extraction of bioactive compounds. It was numerically solved while using finite-difference approximation. The parameters considered were effective diffusivity inside the pericarp (Dep), mass transfer coefficient from the pericarp surface to the solvent (kc), and distribution coefficient (H). The model simulates the extraction performance, including the yield and bioactive compounds’ concentrations in the extract and inside the pericarp at various positions and times. A sensitivity analysis of the changes in each involved parameter provided sufficient information for increasing the performance of the model. A validation test that compared the results of the simulation with those of established analytical solutions showed that the model has high accuracy. Hence, the model can be applied in quantitative evaluations to improve productivity in the pharmaceutical industry. View Full-Text
Keywords: mechanistic; model; process; mass transfer; extraction; bioactive; sorghum; pericarp mechanistic; model; process; mass transfer; extraction; bioactive; sorghum; pericarp
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MDPI and ACS Style

Susanti, D.Y.; Sediawan, W.B.; Fahrurrozi, M.; Hidayat, M. A Mechanistic Model of Mass Transfer in the Extraction of Bioactive Compounds from Intact Sorghum Pericarp. Processes 2019, 7, 837. https://doi.org/10.3390/pr7110837

AMA Style

Susanti DY, Sediawan WB, Fahrurrozi M, Hidayat M. A Mechanistic Model of Mass Transfer in the Extraction of Bioactive Compounds from Intact Sorghum Pericarp. Processes. 2019; 7(11):837. https://doi.org/10.3390/pr7110837

Chicago/Turabian Style

Susanti, Devi Yuni, Wahyudi Budi Sediawan, Mohammad Fahrurrozi, and Muslikhin Hidayat. 2019. "A Mechanistic Model of Mass Transfer in the Extraction of Bioactive Compounds from Intact Sorghum Pericarp" Processes 7, no. 11: 837. https://doi.org/10.3390/pr7110837

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