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Article

Enantioselective Extraction of Phenylalanine Enantiomers Using Environmentally Friendly Aqueous Two-Phase Systems

by 1,†, 3,†, 1,*, 1 and 1,2,*
1
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
2
Institute of Bast Fiber Crops and Center of Southern Economic Crops, Chinese Academy of Agricultural Sciences, Changsha 410205, China
3
School of Chemistry and Chemical Engineering, Qiannan Normal University for Nationalities, Duyun 558000, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Processes 2018, 6(11), 212; https://doi.org/10.3390/pr6110212
Received: 9 October 2018 / Revised: 20 October 2018 / Accepted: 23 October 2018 / Published: 1 November 2018
(This article belongs to the Section Chemical Processes and Systems)
(1) Background: The environmentally friendly choline-amino acid ionic liquids (ChAAILs) and deep eutectic solvents (DESs) have been used as excellent alternatives to volatile organic compounds (VOCs) and ionic liquids (ILs) in recent years; (2) Methods: Thus, ChAAILs/salt and DESs/salt aqueous two-phase systems (ATPSs) were developed for the chiral extraction of phenylalanine enantiomers. The optimum ATPS of [Ch][L-Pro]/K3PO4 was chosen, and the influencing parameters were investigated, including ChAAILs concentration, salt concentration, chiral selector concentration, extraction temperature, phenylalanine concentration, and system pH; (3) Results: The phenylalanine enantiomers were mainly extracted into the top phase (ChAAIL-rich phase), meanwhile, the (S)-phenylalanine [(S)-Phe)] was preferentially recognized by the chiral selector in the top phase. The maximum separation factor (α) of 2.05 was obtained under the optimal conditions; and (4) Conclusions: This ATPS that was used for the chiral extraction of enantiomers is much more environmentally friendly, simple, and rapid, and has the potential to be used in the enantioselective extraction of other enantiomers. View Full-Text
Keywords: enantioselective extraction; aqueous two-phase system; ionic liquids; deep eutectic solvents; phenylalanine enantioselective extraction; aqueous two-phase system; ionic liquids; deep eutectic solvents; phenylalanine
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MDPI and ACS Style

Sun, D.; Wang, R.; Li, F.; Liu, L.; Tan, Z. Enantioselective Extraction of Phenylalanine Enantiomers Using Environmentally Friendly Aqueous Two-Phase Systems. Processes 2018, 6, 212. https://doi.org/10.3390/pr6110212

AMA Style

Sun D, Wang R, Li F, Liu L, Tan Z. Enantioselective Extraction of Phenylalanine Enantiomers Using Environmentally Friendly Aqueous Two-Phase Systems. Processes. 2018; 6(11):212. https://doi.org/10.3390/pr6110212

Chicago/Turabian Style

Sun, Danyu, Runping Wang, Fenfang Li, Lianglei Liu, and Zhijian Tan. 2018. "Enantioselective Extraction of Phenylalanine Enantiomers Using Environmentally Friendly Aqueous Two-Phase Systems" Processes 6, no. 11: 212. https://doi.org/10.3390/pr6110212

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