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Volume 10
Issue 8
10.3390/pr10081595
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Review

Strain Development, Substrate Utilization, and Downstream Purification of Vitamin C

by
Alexandra Tucaliuc
,
Ana Cîșlaru
,
Lenuţa Kloetzer
and
Alexandra Cristina Blaga
*
Department of Organic, Biochemical and Food Engineering, Faculty of Chemical Engineering and Environmental Protection, “Gheorghe Asachi” Technical University of Iasi, 173 D. Mangeron, 700050 Iasi, Romania
*
Author to whom correspondence should be addressed.
Processes 2022, 10(8), 1595; https://doi.org/10.3390/pr10081595
Submission received: 15 July 2022 / Revised: 30 July 2022 / Accepted: 9 August 2022 / Published: 12 August 2022
(This article belongs to the Special Issue Microbiotechnology in Cosmetics, Pharmaceuticals and Food)
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Abstract

Vitamin C, C6H8O6, is a water-soluble vitamin that is widespread in nature. It is an essential nutrient involved in many biological processes in the living organisms: it enhances collagen biosynthesis, ensures the optimal functioning of enzymes and the immune system, has a major role in lipid and iron metabolism, and it enhances the biosynthesis of l-carnitine. Due to its antioxidant activity, vitamin C can neutralize the tissue-damaging effects of free radicals. Vitamin C is being related to the prevention of cancer and cardiovascular diseases. This review includes current information on the biosynthesis of ascorbic acid, as new methods are now challenging the traditional Reichstein process for vitamin C’s industrial-scale production. Different strains were analyzed in correlation with their ability to synthesize ascorbic acid, and several separation techniques were investigated for a more effective production of vitamin C.
Keywords: vitamin C; biosynthesis; Reichstein process; two-step fermentation process vitamin C; biosynthesis; Reichstein process; two-step fermentation process
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MDPI and ACS Style

Tucaliuc, A.; Cîșlaru, A.; Kloetzer, L.; Blaga, A.C. Strain Development, Substrate Utilization, and Downstream Purification of Vitamin C. Processes 2022, 10, 1595. https://doi.org/10.3390/pr10081595

AMA Style

Tucaliuc A, Cîșlaru A, Kloetzer L, Blaga AC. Strain Development, Substrate Utilization, and Downstream Purification of Vitamin C. Processes. 2022; 10(8):1595. https://doi.org/10.3390/pr10081595

Chicago/Turabian Style

Tucaliuc, Alexandra, Ana Cîșlaru, Lenuţa Kloetzer, and Alexandra Cristina Blaga. 2022. "Strain Development, Substrate Utilization, and Downstream Purification of Vitamin C" Processes 10, no. 8: 1595. https://doi.org/10.3390/pr10081595

APA Style

Tucaliuc, A., Cîșlaru, A., Kloetzer, L., & Blaga, A. C. (2022). Strain Development, Substrate Utilization, and Downstream Purification of Vitamin C. Processes, 10(8), 1595. https://doi.org/10.3390/pr10081595

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