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Article

GC–MS-Based Metabolites Profiling, In Vitro Antioxidant, Anticancer, and Antimicrobial Properties of Different Solvent Extracts from the Botanical Parts of Micromeria fruticosa (Lamiaceae)

1
Department of Chemistry, An-Najah National University, P.O. Box. 7, Nablus 415, Palestine
2
School of Science and the Environment, Grenfell Campus, Memorial University of Newfoundland, Corner Brook, NL A2H 5G4, Canada
3
The Functional Foods Sensory Laboratory, Grenfell Campus, Memorial University of Newfoundland, Corner Brook, NL A2H 5G4, Canada
4
Department of Biology and Biotechnology, An-Najah National University, P.O. Box. 7, Nablus 415, Palestine
5
Faculty of Pharmacy, Arab American University, Jenin P.O. Box 249, Zababdeh 13, Palestine
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Bonglee Kim
Processes 2022, 10(5), 1016; https://doi.org/10.3390/pr10051016
Received: 4 April 2022 / Revised: 6 May 2022 / Accepted: 16 May 2022 / Published: 19 May 2022
The present study assessed the metabolites and bioactivities of Micromeria fruticosa plant parts extracted with various solvents (ethanol, n-hexane, and water) through the steeping extraction method. Thereafter, the extracts were analyzed using GC-MS. Moreover, the extracts were tested for their antioxidant, antimicrobial, and antitumor activities. The quali-quantitative analysis of Micromeria fruticosa crude extracts revealed the occurrence of 27 secondary metabolites. Some major bioactives identified were menthone, oleamide, pulegone, and menthol. Numerous antioxidant minerals, viz., Fe, Zn, and Mn, were present. The water extract of leaves exhibited the highest DPPH scavenging activity (89.73%), followed by the water extract of flowers (80.07%) at 100 μg/mL. The stems’ water extract demonstrated greater antimicrobial activity against all the bacteria species tested. The ethanolic leaf and aqueous stem extracts exhibited strong activity against C. albicans and E. coli. Flowers’ aqueous extract demonstrated the highest cytostatic effect on the colon cell line by reducing viability, followed by the leaves’ ethanol extract. The extraction solvents influenced the recovery of phytocompounds, and the highest pharmacological activities of the different extracts could be correlated to the presence of additional bioactives. Our results suggest that the Micromeria fruticosa plant is a favorable source of natural products with promising properties for potential nutraceutical and functional food applications. View Full-Text
Keywords: Micromeria fruticosa; GC-MS; metabolites; antitumor activity; MTT; antimicrobial activity; antioxidant activity Micromeria fruticosa; GC-MS; metabolites; antitumor activity; MTT; antimicrobial activity; antioxidant activity
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MDPI and ACS Style

Al-Nuri, M.; Abu-Reidah, I.M.; Alhajeh, A.A.; Omar, G.; Adwan, G.; Warad, I. GC–MS-Based Metabolites Profiling, In Vitro Antioxidant, Anticancer, and Antimicrobial Properties of Different Solvent Extracts from the Botanical Parts of Micromeria fruticosa (Lamiaceae). Processes 2022, 10, 1016. https://doi.org/10.3390/pr10051016

AMA Style

Al-Nuri M, Abu-Reidah IM, Alhajeh AA, Omar G, Adwan G, Warad I. GC–MS-Based Metabolites Profiling, In Vitro Antioxidant, Anticancer, and Antimicrobial Properties of Different Solvent Extracts from the Botanical Parts of Micromeria fruticosa (Lamiaceae). Processes. 2022; 10(5):1016. https://doi.org/10.3390/pr10051016

Chicago/Turabian Style

Al-Nuri, Mohammad, Ibrahim M. Abu-Reidah, Anwar A. Alhajeh, Ghadeer Omar, Ghaleb Adwan, and Ismail Warad. 2022. "GC–MS-Based Metabolites Profiling, In Vitro Antioxidant, Anticancer, and Antimicrobial Properties of Different Solvent Extracts from the Botanical Parts of Micromeria fruticosa (Lamiaceae)" Processes 10, no. 5: 1016. https://doi.org/10.3390/pr10051016

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