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Review
Peer-Review Record

Going the Extra Mile: Why Clinical Research in Cystic Fibrosis Must Include Children

Children 2022, 9(7), 1080; https://doi.org/10.3390/children9071080
by Rebecca Dobra 1,2,*, Siân Bentley 1,3, Claire Edmondson 1,2, Maxine Ovens 4, Clare Saunders 1,2, Christopher Short 1, Gemma Wilson 2, Jane C. Davies 1,2 and Andrew Bush 2,5
Reviewer 1:
Reviewer 2:
Children 2022, 9(7), 1080; https://doi.org/10.3390/children9071080
Submission received: 4 July 2022 / Accepted: 14 July 2022 / Published: 20 July 2022
(This article belongs to the Special Issue Cystic Fibrosis in Children)

Round 1

Reviewer 1 Report

Trank you very much for this interesting manuscript

Reviewer 2 Report

An excellent manuscript!

Reviewer 3 Report

In this valuable review, Dobra and colleagues argue the need for clinical trials involving children with CF. Most of the time, therapeutic regimens for children with CF are determined based on clinical trials performed on adults. However, children - especially infants and very young children- differ significantly in their physiology and how they respond to medication compared to adults. However, involving very young children in clinical research comes with a set of ethical, social, administrative, and technical hurdles that have to be overcome. Raising awareness for such issues and opening such subjects to public debate is of crucial importance. I find the review very well written, organized, and with a very logical flow, the reason for which I support its publication in its current form.

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