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Article

Feasibility of Real-Time Central Surgical Review for Patients with Advanced-Stage Hepatoblastoma in the JPLT3 Trial

by
Tomoro Hishiki
1,*,
Shohei Honda
2,
Yuichi Takama
3,
Yukihiro Inomata
4,
Hideaki Okajima
5,
Ken Hoshino
6,
Tatsuya Suzuki
7,
Ryota Souzaki
8,
Motoshi Wada
9,
Mureo Kasahara
10,
Koichi Mizuta
11,
Takaharu Oue
12,
Akiko Yokoi
13,
Takuro Kazama
9,
Shugo Komatsu
1,
Isamu Saeki
14,
Osamu Miyazaki
15,
Tetsuya Takimoto
16,
Kohmei Ida
17,
Kenichiro Watanabe
18 and
Eiso Hiyama
14,19add Show full author list remove Hide full author list
1
Department of Pediatric Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Chiba, Japan
2
Department of Gastroenterological Surgery I, Hokkaido University Hospital, Sapporo 060-8648, Hokkaido, Japan
3
Department of Pediatric Surgery, Osaka City General Hospital, Osaka 534-0021, Osaka, Japan
4
Kumamoto Rosai Hospital, Yatsushiro 866-8533, Kumamoto, Japan
5
Department of Pediatric Surgery, Kanazawa Medical University, Kanazawa 920-0293, Ishikawa, Japan
6
Department of Pediatric Surgery, Keio School of Medicine, Keio University, Tokyo 108-8345, Tokyo, Japan
7
Department of Pediatric Surgery, Fujita Health University Hospital, Toyoake 470-1192, Aichi, Japan
8
Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Fukuoka, Japan
9
Department of Pediatric Surgery, Tohoku University School of Medicine, Sendai 980-8574, Miyagi, Japan
10
Organ Transplantation Center, National Center for Child Health and Development, Tokyo 157-8535, Tokyo, Japan
11
Transplant Center, Saitama Children’s Medical Center, Saitama 330-8777, Saitama, Japan
12
Department of Pediatric Surgery, Hyogo College of Medicine, Nishinomiya 663-8501, Hyogo, Japan
13
Department of Pediatric Surgery, Kobe Children’s Hospital, Kobe 650-0047, Hyogo, Japan
14
Department of Pediatric Surgery, Hiroshima University Hospital, Hiroshima 734-8551, Hiroshima, Japan
15
Department of Diagnostic Radiology, National Center for Child Health and Development, Tokyo 157-8535, Tokyo, Japan
16
Department of Childhood Cancer Data Management, National Center for Child Health and Development, Tokyo 157-8535, Tokyo, Japan
17
Department of Pediatrics, Teikyo University Mizonokuchi Hospital, Kawasaki 213-8507, Kanagawa, Japan
18
Department of Hematology and Oncology, Shizuoka Children’s Hospital, Shizuoka 420-8660, Shizuoka, Japan
19
Natural Science Center for Basic Research and Development, Hiroshima University, Hiroshima 734-8551, Hiroshima, Japan
 
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*
Author to whom correspondence should be addressed.
Children 2022, 9(2), 234; https://doi.org/10.3390/children9020234
Submission received: 30 December 2021 / Revised: 1 February 2022 / Accepted: 5 February 2022 / Published: 10 February 2022
(This article belongs to the Special Issue Surgical Management for Children with Primary Liver Tumors)
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Abstract

In the JPLT3 study, a real-time central surgical reviewing (CSR) system was employed aimed at facilitating early referral of candidates for liver transplantation (LTx) to centers with pediatric LTx services. The expected consequence was surgery, including LTx, conducted at the appropriate time in all cases. This study aimed to review the effect of CSR on institutional surgical decisions in cases enrolled in the JPLT3 study. Real-time CSR was performed in cases in which complex surgeries were expected, using images obtained after two courses of preoperative chemotherapy. Using the cloud-based remote image viewing system, an expert panel consisting of pediatric and transplant surgeons reviewed the images and commented on the expected surgical strategy or the necessity of transferring the patient to a transplant unit. The results were summarized and reported to the treating institutions. A total of 41 reviews were conducted for 35 patients, and 16 cases were evaluated as possible candidates for LTx, with the treating institutions being advised to consult a transplant center. Most of the reviewed cases promptly underwent definitive liver surgeries, including LTx per protocol.
Keywords: hepatoblastoma; clinical trial; surgery; central review; cloud-based remote image viewing system; liver transplantation hepatoblastoma; clinical trial; surgery; central review; cloud-based remote image viewing system; liver transplantation

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MDPI and ACS Style

Hishiki, T.; Honda, S.; Takama, Y.; Inomata, Y.; Okajima, H.; Hoshino, K.; Suzuki, T.; Souzaki, R.; Wada, M.; Kasahara, M.; et al. Feasibility of Real-Time Central Surgical Review for Patients with Advanced-Stage Hepatoblastoma in the JPLT3 Trial. Children 2022, 9, 234. https://doi.org/10.3390/children9020234

AMA Style

Hishiki T, Honda S, Takama Y, Inomata Y, Okajima H, Hoshino K, Suzuki T, Souzaki R, Wada M, Kasahara M, et al. Feasibility of Real-Time Central Surgical Review for Patients with Advanced-Stage Hepatoblastoma in the JPLT3 Trial. Children. 2022; 9(2):234. https://doi.org/10.3390/children9020234

Chicago/Turabian Style

Hishiki, Tomoro, Shohei Honda, Yuichi Takama, Yukihiro Inomata, Hideaki Okajima, Ken Hoshino, Tatsuya Suzuki, Ryota Souzaki, Motoshi Wada, Mureo Kasahara, and et al. 2022. "Feasibility of Real-Time Central Surgical Review for Patients with Advanced-Stage Hepatoblastoma in the JPLT3 Trial" Children 9, no. 2: 234. https://doi.org/10.3390/children9020234

APA Style

Hishiki, T., Honda, S., Takama, Y., Inomata, Y., Okajima, H., Hoshino, K., Suzuki, T., Souzaki, R., Wada, M., Kasahara, M., Mizuta, K., Oue, T., Yokoi, A., Kazama, T., Komatsu, S., Saeki, I., Miyazaki, O., Takimoto, T., Ida, K., ... Hiyama, E. (2022). Feasibility of Real-Time Central Surgical Review for Patients with Advanced-Stage Hepatoblastoma in the JPLT3 Trial. Children, 9(2), 234. https://doi.org/10.3390/children9020234

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