Acute Mild Pancreatitis Following COVID-19 mRNA Vaccine in an Adolescent
Abstract
1. Introduction
2. Case Presentation
3. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Wolff, J.A.; Malone, R.W.; Williams, P.; Chong, W.; Acsadi, G.; Jani, A.; Felgner, P.L. Direct gene transfer into mouse muscle in vivo. Science 1990, 247, 1465–1468. [Google Scholar] [CrossRef] [PubMed]
- Karikó, K.; Weissman, D. Naturally occurring nucleoside modifications suppress the immunostimulatory activity of RNA: Im-plication for therapeutic RNA development. Curr. Opin. Drug Discov. Devel. 2007, 10, 523–532. [Google Scholar] [PubMed]
- Petsch, B.; Schnee, M.; Vogel, A.B.; Lange, E.; Hoffmann, B.; Voss, D.; Schlake, T.; Thess, A.; Kallen, K.-J.; Stitz, L.; et al. Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection. Nat. Biotechnol. 2012, 30, 1210–1216. [Google Scholar] [CrossRef] [PubMed]
- Huang, C.; Wang, Y.; Li, X.; Ren, L.; Zhao, J.; Hu, Y.; Zhang, L.; Fan, G.; Xu, J.; Gu, X.; et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020, 395, 497–506. [Google Scholar] [CrossRef]
- Sahin, U.; Muik, A.; Derhovanessian, E.; Vogler, I.; Kranz, L.M.; Vormehr, M.; Baum, A.; Pascal, K.; Quandt, J.; Maurus, D.; et al. COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T-cell responses. Nature 2020, 586, 594–599. [Google Scholar] [CrossRef] [PubMed]
- Abu-El-Haija, M.; Kumar, S.; Quiros, J.A.; Balakrishnan, K.; Barth, B.; Bitton, S.; Eisses, J.F.; Foglio, E.J.; Fox, V.; Francis, D.; et al. Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report from the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas Committee. J. Pediatr. Gastroenterol. Nutr. 2018, 66, 159–176. [Google Scholar] [CrossRef] [PubMed]
- Polack, F.P.; Thomas, S.J.; Kitchin, N.; Absalon, J.; Gurtman, A.; Lockhart, S.; Perez, J.L.; Marc, G.P.; Moreira, E.D.; Zerbini, C.; et al. Safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine. N. Engl. J. Med. 2020, 383, 2603–2615. [Google Scholar] [CrossRef] [PubMed]
- Pfizer-BioNTech COVID-19 Vaccine (BNT162, PF-07302048) Vaccines and Related Biological Products Advisory Committee. Briefing Document. Meeting Date: 10 December 2020. US Food and Drug Administration 2020 14 December. [Ref. ID 103835]. Available online: https://www.fda.gov/media/144246/download (accessed on 7 August 2021).
- COVID-19 mRNA Pfizer-BioNTech Vaccine Analysis Print. All UK Spontaneous Reports Received Between 9 December 2020 and 30 June 2021 for mRNA Pfizer/BioNTech Vaccine Analysis Print. Available online: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1009453/COVID-19_mRNA_Pfizer-BioNTech_Vaccine_Analysis_Print_DLP_28.07.2021.pdf (accessed on 7 August 2021).
- Point de Situation sur la Surveillance des Vaccins Contre la COVID-19—Période du 9 July 2021 au 15 July 2021. L’Agence Na-tionale de Sécurité du Médicament et des Produits de Santé or ANSM. Available online: https://www.ansm.sante.fr (accessed on 7 August 2021).
- WHO. VigiAccess. Available online: http://www.vigiaccess.org (accessed on 7 August 2021).
- Parkash, O.; Sharko, A.; Farooqi, A.; Ying, G.W.; Sura, P. Acute Pancreatitis: A Possible Side Effect of COVID-19 Vaccine. Cureus 2021, 13, 14741. [Google Scholar] [CrossRef] [PubMed]
- Walter, T.; Connor, S.; Stedman, C.; Doogue, M. A case of acute necrotizing pancreatitis following the second dose of Pfizer-BioNTech COVID-19 mRNA vaccine. Authorea 2021. [Google Scholar] [CrossRef]
- Cieślewicz, A.; Dudek, M.; Krela-Kaźmierczak, I.; Jabłecka, A.; Lesiak, M.; Korzeniowska, K. Pancreatic Injury after COVID-19 Vaccine—A Case Report. Vaccines 2021, 9, 576. [Google Scholar] [CrossRef] [PubMed]
- Adler, J.B.; Mazzotta, S.A.; Barkin, J.S. Pancreatitis Caused by Measles, Mumps, and Rubella Vaccine. Pancreas 1991, 6, 489–490. [Google Scholar] [CrossRef] [PubMed]
- Cebriá, L.; Roldán, F.P.; Sanchez, E.; Rodrícuez-Laiz, J.M.; Casado, M.; Robles, J.; González-Lam, V.; Cos, E. Acute Pancreatitis Caused by Parotiditis Vaccine. Pancreas 1994, 9, 390–391. [Google Scholar] [CrossRef] [PubMed]
- Feldman, G.; Zer, M. Infantile acute pancreatitis after mumps vaccination simulating an acute abdomen. Pediatr. Surg. Int. 2000, 16, 488–489. [Google Scholar] [CrossRef] [PubMed]
- Shlomovitz, E.; Davies, W.; Cairns, E.; Brintnell, W.C.; Goldszmidt, M.; Dresser, G.K. Severe necrotizing pancreatitis following combined hepatitis A and B vaccination. Can. Med Assoc. J. 2007, 176, 339–342. [Google Scholar] [CrossRef] [PubMed][Green Version]
- Bizjak, M.; Bruck, O.; Praprotnik, S.; Dahan, S.; Shoenfeld, Y. Pancreatitis after human papillomavirus vaccination: A matter of molecular mimicry. Immunol. Res. 2017, 65, 164–167. [Google Scholar] [CrossRef] [PubMed]
Parameter | Blood Level (Normal Range) |
---|---|
Lipase | 1535 (70–390) U/L |
Amylase | 161 (25–115) U/L |
Triglyceride | 68 (90–129) mg/dL |
Cholesterol | 83 (100–200) mg/dL |
Sodium | 140 (136–145) mEq/L |
Potassium | 4.5 (3.4–5.3) mEq/L |
Chloride | 107 (95–112) mEq/L |
Calcium | 9.3 (8.5–10.1) mg/dL |
Alanine aminotransferase | 34 (6–43) U/L |
Aspartate aminotransferase | 27 (3–37) U/L |
Gammaglutamyl transferase | 37 (3–65) U/L |
Bilirubin | 0.86 (0.2–1.0) mg/dL |
Alkaline phosphatase | 79 (70–935) U/L |
Urea nitrogen | 24 (16–45) mg/dL |
Creatinine | 0.88 (0.67–1.17) mg/dL |
Glucose | 90 (74–106) mg/dL |
White blood cells | 9.3 × 109/L (3.4–9.6 × 109/L) |
Neutrophils | 4.48 × 109/L |
Lymphocyte | 4.1 × 109/L |
Monocytes | 0.4 × 109/L |
Eosinophils | 0.3 × 109/L |
Basophils | 0.1 × 109/L |
Red blood cells | 5.22 × 1012/L (4.35–5.65 × 1012/L) |
Haemoglobin | 15.5 (13.2–16.6) gr/dL |
Platelets | 188 × 109/L (135–317 × 109/L) |
Tryptase | 4 (<11) ug/L |
D-dimer | <0.5 (<0.5) ug/mL |
Troponin I | <0.015 (<0.015) ng/mL |
N-terminal pro B-type natriuretic peptide | <5 (5–363) pg/mL |
Procalcitonin | <0.05 (<0.05) ng/mL |
C-reactive protein | <0.29 (<0.29) mg/dL |
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Kantar, A.; Seminara, M.; Odoni, M.; Dalla Verde, I. Acute Mild Pancreatitis Following COVID-19 mRNA Vaccine in an Adolescent. Children 2022, 9, 29. https://doi.org/10.3390/children9010029
Kantar A, Seminara M, Odoni M, Dalla Verde I. Acute Mild Pancreatitis Following COVID-19 mRNA Vaccine in an Adolescent. Children. 2022; 9(1):29. https://doi.org/10.3390/children9010029
Chicago/Turabian StyleKantar, Ahmad, Manuela Seminara, Marta Odoni, and Ilaria Dalla Verde. 2022. "Acute Mild Pancreatitis Following COVID-19 mRNA Vaccine in an Adolescent" Children 9, no. 1: 29. https://doi.org/10.3390/children9010029
APA StyleKantar, A., Seminara, M., Odoni, M., & Dalla Verde, I. (2022). Acute Mild Pancreatitis Following COVID-19 mRNA Vaccine in an Adolescent. Children, 9(1), 29. https://doi.org/10.3390/children9010029