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Open AccessCase Report

Chronic Pancytopenia Due to Centrally Mediated Hypothermia in Two Children with Severe Neurological Impairment

1
Division of General and Community Pediatrics, Children’s National Hospital, Washington, DC 20110, USA
2
Division of General Pediatrics, Boston Children’s Hospital, Boston, MA 02115, USA
3
Seven Hills Pediatric Center, Groton, MA 01450, USA
*
Author to whom correspondence should be addressed.
Children 2020, 7(4), 31; https://doi.org/10.3390/children7040031
Received: 11 February 2020 / Revised: 6 March 2020 / Accepted: 1 April 2020 / Published: 8 April 2020
We report on recurrent pancytopenia over five years in two children with severe impairment of the central nervous system. Assessment by hematology did not identify an etiology, including bone marrow biopsy in one. Both patients had sustained normalized blood cell counts following interventions to maintain or return to a temperature above 33 °C. Acute cytopenias following medically induced and environmental hypothermia have been reported. Recurrent pancytopenia due to centrally mediated hypothermia in patients with severe neurological impairment is often not recognized, putting such children at risk for unnecessary testing and transfusions. We provide a practical approach to management that is feasible for caregivers in the home setting with suggestions for monitoring. View Full-Text
Keywords: neurological impairment; cerebral palsy; neurodisability; hypothermia; thrombocytopenia; pancytopenia; children neurological impairment; cerebral palsy; neurodisability; hypothermia; thrombocytopenia; pancytopenia; children
MDPI and ACS Style

Fratantoni, K.; Hauer, J.M. Chronic Pancytopenia Due to Centrally Mediated Hypothermia in Two Children with Severe Neurological Impairment. Children 2020, 7, 31.

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