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Volume 11
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10.3390/children11060737
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Article

Identifying Key Biomarkers in Pediatric Pulmonary Hypertension: An Investigative Approach

by
Farida Mindubayeva
1,
Lyudmila Akhmaltdinova
2,
Mariya Ospanova
1,*,
Bibigul Tukbekova
3,
Zhanat Bolatbekuly
4,
Yuliya Niyazova
1,
Yelena Salikhova
1,
Olga Avdienko
2 and
Meruert Akhmetova
1
1
Department of Physiology, NCJSC «Karaganda Medical University», Karaganda 100000, Kazakhstan
2
Scientific Research Laboratory, NCJSC «Karaganda Medical University», Karaganda 100000, Kazakhstan
3
Department of Pediatrics and Neonatology, NCJSC «Karaganda Medical University», Karaganda 100000, Kazakhstan
4
Municipal State Enterprise «Multiprofile Hospital No. 2 of Karaganda», Health Department of the Karaganda Region, Karaganda 100000, Kazakhstan
*
Author to whom correspondence should be addressed.
Children 2024, 11(6), 737; https://doi.org/10.3390/children11060737
Submission received: 20 April 2024 / Revised: 29 May 2024 / Accepted: 6 June 2024 / Published: 17 June 2024
(This article belongs to the Section Pediatric Pulmonary and Sleep Medicine)
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Abstract

This study assesses the utility of early biomarkers—5-hydroxyindoleacetic acid (5-HIAA) and insulin-like growth factor 1 (IGF-1)—for diagnosing and monitoring pulmonary hypertension (PH) in children with congenital heart defects (CHD). Due to the risks associated with invasive diagnostics, such as right heart catheterization, non-invasive biomarkers provide a safer alternative for early PH detection. This cohort-based study utilized blood and urine samples to measure 5-HIAA and IGF-1 levels via enzyme immunoassays. Our findings revealed significant changes in 5-HIAA concentrations across various biological matrices, supporting its potential as a diagnostic tool. Specifically, altered levels in urine and plasma reflect its role in serotonin metabolism and vascular remodeling in PH. IGF-1 levels were notably reduced in plasma, suggesting its involvement in PH pathophysiology. ROC analysis confirmed the diagnostic efficacy of these biomarkers, particularly 5-HIAA’s high specificity and sensitivity. In conclusion, 5-HIAA and IGF-1 levels correlate well with PH, underscoring their diagnostic value for early PH detection in children with CHD.
Keywords: 5-hydroxyindoleacetic acid; children; congenital heart defects; insulin-like growth factor 1; pulmonary hypertension 5-hydroxyindoleacetic acid; children; congenital heart defects; insulin-like growth factor 1; pulmonary hypertension

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MDPI and ACS Style

Mindubayeva, F.; Akhmaltdinova, L.; Ospanova, M.; Tukbekova, B.; Bolatbekuly, Z.; Niyazova, Y.; Salikhova, Y.; Avdienko, O.; Akhmetova, M. Identifying Key Biomarkers in Pediatric Pulmonary Hypertension: An Investigative Approach. Children 2024, 11, 737. https://doi.org/10.3390/children11060737

AMA Style

Mindubayeva F, Akhmaltdinova L, Ospanova M, Tukbekova B, Bolatbekuly Z, Niyazova Y, Salikhova Y, Avdienko O, Akhmetova M. Identifying Key Biomarkers in Pediatric Pulmonary Hypertension: An Investigative Approach. Children. 2024; 11(6):737. https://doi.org/10.3390/children11060737

Chicago/Turabian Style

Mindubayeva, Farida, Lyudmila Akhmaltdinova, Mariya Ospanova, Bibigul Tukbekova, Zhanat Bolatbekuly, Yuliya Niyazova, Yelena Salikhova, Olga Avdienko, and Meruert Akhmetova. 2024. "Identifying Key Biomarkers in Pediatric Pulmonary Hypertension: An Investigative Approach" Children 11, no. 6: 737. https://doi.org/10.3390/children11060737

APA Style

Mindubayeva, F., Akhmaltdinova, L., Ospanova, M., Tukbekova, B., Bolatbekuly, Z., Niyazova, Y., Salikhova, Y., Avdienko, O., & Akhmetova, M. (2024). Identifying Key Biomarkers in Pediatric Pulmonary Hypertension: An Investigative Approach. Children, 11(6), 737. https://doi.org/10.3390/children11060737

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