Clinical Relevance of Pathological Diagnosis of Hirschsprung’s Disease with Acetylcholine-Esterase Histochemistry or Calretinin Immunohistochemistry
Abstract
1. Introduction
2. Methods
3. Results
4. Discussion
5. Limitations
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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AChE Group | (n = 17) | CR Group | (n = 12) | p Value | |
---|---|---|---|---|---|
n | Percent (%) | n | Percent (%) | ||
Female | 2 | 11.8 | 1 | 8.3 | n.s. |
Male | 15 | 88.2 | 11 | 91.7 | n.s. |
Length of affected segment | |||||
-Rectosigmoid | 10 | 58.8 | 10 | 83.3 | n.s. |
-Colon | 5 | 29.4 | 2 | 16.7 | n.s. |
-Jirásek–Zuelzer–Wilson | 2 | 11.8 | / | / | n.s. |
Associated congenital anomalies | 7 | 41.2 | 6 | 50 | n.s. |
Down syndrome | 3 | 17.6 | 4 | 33.3 | n.s. |
Enterostomy prior to pull-through | 8 | 47.1 | 3 | 25 | n.s. |
TERPT | 12 | 70.6 | 10 | 83.3 | n.s. |
TERPT with laparotomy | 3 | 17.6 | 2 | 16.7 | n.s. |
TERPT with laparoscopy | 2 | 11.8 | / | / | n.s. |
AChE Group | (n = 17) | CR Group | (n = 12) | p Value | |||||
---|---|---|---|---|---|---|---|---|---|
Mean | SD | Median | Mean | SD | Median | U | Z | ||
Weeks of pregnancy | 38.8 | 1.4 | 39 | 38.0 | 1.5 | 38 | 76.5 | −1.175 | n.s. |
Birth weight (g) | 3329 | 572 | 3270 | 3114 | 669 | 2927.5 | 78 | −1.062 | n.s. |
Age at rectal biopsy (days) | 106.3 | 65.3 | 100 | 32.5 | 25.5 | 25 | 27 | −3.321 | 0.000 |
Age at TERPT (days) | 252 | 315 | 124 | 68 | 33 | 62 | 32.5 | −3.077 | 0.001 |
Weight at TERPT (kg) | 6.8 | 2.6 | 6 | 4.4 | 1.1 | 4.5 | 40.5 | −2.725 | 0.005 |
Length of intestinal resection (cm) | 31.6 | 14.7 | 27 | 23.3 | 6.2 | 21.5 | 69 | −1.470 | n.s |
Length of aganglionic segment (cm) | 16.7 | 15.1 | 8 | 10.7 | 7.5 | 8.5 | 84 | −0.802 | n.s. |
TERPT operative time (min) | 172.2 | 63.0 | 156 | 178.0 | 40.6 | 167.5 | 88 | −0.621 | n.s. |
Length of hospital stay (days) | 9.2 | 3.0 | 9 | 10.1 | 9.9 | 7.0 | 74 | −1.252 | n.s. |
AChE Group | (n = 17) | CR Group | (n = 12) | p Value | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
n | Mean | SD | Median | n | Mean | SD | Median | U | Z | ||
Duration of constipation (month) | 5 | 5.2 | 3.4 | 6 | 8 | 3.1 | 2.7 | 3 | 13.5 | −0.976 | n.s. |
Bowel movements (per week) | 17 | 22.8 | 17.9 | 20 | 12 | 14.5 | 9.5 | 14 | 72.5 | −1.315 | n.s. |
Stool consistency * | 17 | 4.8 | 0.9 | 5 | 12 | 4.5 | 0.5 | 5 | 77.0 | −1.192 | n.s. |
Duration of enterostomy (month) | 8 | 12.7 | 14.5 | 5 | 3 | 2.0 | 1.7 | 1 | 2.5 | −1.990 | 0.048 |
AChE Group | (n = 17) | CR Group | (n = 12) | p Value | |
---|---|---|---|---|---|
n | Percent (%) | n | Percent (%) | ||
Partial anastomotic dehiscence | 1 | 5.9 | / | / | n.s. |
Anorectal stenosis | 6 | 35.3 | 4 | 33.3 | n.s. |
Ileus | 1 | 5.9 | / | / | n.s. |
Enterocolitis post TERPT | 2 | 11.8 | 3 | 25 | n.s. |
Enterocolitis pre TERPT | 1 | 5.9 | 1 | 8.3 | n.s. |
Constipation | 5 | 29.4 | 8 | 66.7 | n.s. |
Sphinctary Botox treatment | 6 | 35.3 | 7 | 58.3 | n.s. |
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Romero, P.; Burger, A.; Wennberg, E.; Schmitteckert, S.; Holland-Cunz, S.; Schwab, C.; Günther, P. Clinical Relevance of Pathological Diagnosis of Hirschsprung’s Disease with Acetylcholine-Esterase Histochemistry or Calretinin Immunohistochemistry. Children 2024, 11, 428. https://doi.org/10.3390/children11040428
Romero P, Burger A, Wennberg E, Schmitteckert S, Holland-Cunz S, Schwab C, Günther P. Clinical Relevance of Pathological Diagnosis of Hirschsprung’s Disease with Acetylcholine-Esterase Histochemistry or Calretinin Immunohistochemistry. Children. 2024; 11(4):428. https://doi.org/10.3390/children11040428
Chicago/Turabian StyleRomero, Philipp, Astrid Burger, Erica Wennberg, Stefanie Schmitteckert, Stefan Holland-Cunz, Constantin Schwab, and Patrick Günther. 2024. "Clinical Relevance of Pathological Diagnosis of Hirschsprung’s Disease with Acetylcholine-Esterase Histochemistry or Calretinin Immunohistochemistry" Children 11, no. 4: 428. https://doi.org/10.3390/children11040428
APA StyleRomero, P., Burger, A., Wennberg, E., Schmitteckert, S., Holland-Cunz, S., Schwab, C., & Günther, P. (2024). Clinical Relevance of Pathological Diagnosis of Hirschsprung’s Disease with Acetylcholine-Esterase Histochemistry or Calretinin Immunohistochemistry. Children, 11(4), 428. https://doi.org/10.3390/children11040428