Current Uses of Bromelain in Children: A Narrative Review
Abstract
:1. Introduction
2. Methods
3. Effects of Bromelain
4. Pharmacological Profile
4.1. Toxicity and Side Effects
4.2. Methods of Extraction, Purification, and Stabilizing
5. Use of Bromelain in Children and Adolescents
5.1. Upper Respiratory Tract Infections
5.2. Systemic Infections (Sepsis)
5.3. Dental Disorders
5.4. Burns and Associated Complications
6. Conclusions and Future Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Clinical Indication |
---|
Upper Respiratory Tract infections
|
Oral surgery and dentistry
|
Burns |
Author, Year [ref.] | Study Design | Study Population | Type of Disease Treated | Results |
---|---|---|---|---|
Peixoto et al., 2016 [57] | pragmatic, double-blind, randomized, parallel-group study | 60 children aged 2–15 years | irritative cough (for at least 24 h) | The rate of cough improvement was similar in patients treated with pineapple comosus extract + honey (Bromelin®) compared to those receiving honey alone (placebo). |
Braun et al., 2005 [58] | multicentric, epidemiological cohort study | 116 children aged < 11 years | acute sinusitis | The monotherapy group (verum) had a shorter mean symptom duration (6.66 days) and significantly faster symptom resolution (p = 0.005) than the other groups. |
Buttner et al., 2013 [78] | prospective, open-label observational pilot study | 12 patients aged > 25 years | CRS (with or without nasal polyps) previously treated with sinus surgery | Adjunctive treatment with bromelain had positive effects on symptom reduction and quality of life. |
De Luca et al., 2023 [63] | prospective case-control study | 60 patients (children > 12 years adolescents and adults) | chronic sinusitis without nasal polyps (according to clinical EPOS classification) | Bromelain, Ribes nigrum, Boswellia serrata (Casperome®), and vitamin D added to standard topical treatment of chronic sinusitis may reduce mucosal inflammation and improve symptoms. |
Cervo et al., 2014 [64] | randomized controlled trial | 98 schoolchildren | Evaluation of effects of canned pineapple on the physical health, immune modulation, and nutritional status | In both groups that consumed pineapple, the incidence of infection was reduced, with increased granulocyte production. |
Della Volpe et al., 2022 [65] | prospective case-control study | 120 children aged > 12 months | OME and conductive hearing loss | Auditory, otoscopic, and fibroscopic findings improved in the group treated for 30 days compared to the control group, with a positive impact on patient well-being. |
Coelho Dos Reis et al., 2022 [81] | blinded crossover study | 20 COVID-19 patients aged ≥ 18 years | Critical COVID-19 (requiring mechanical ventilation) | Strong mucolytic effect of bromelain on COVID-19 sputum and anti-inflammatory activity. |
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Locci, C.; Chicconi, E.; Antonucci, R. Current Uses of Bromelain in Children: A Narrative Review. Children 2024, 11, 377. https://doi.org/10.3390/children11030377
Locci C, Chicconi E, Antonucci R. Current Uses of Bromelain in Children: A Narrative Review. Children. 2024; 11(3):377. https://doi.org/10.3390/children11030377
Chicago/Turabian StyleLocci, Cristian, Elena Chicconi, and Roberto Antonucci. 2024. "Current Uses of Bromelain in Children: A Narrative Review" Children 11, no. 3: 377. https://doi.org/10.3390/children11030377
APA StyleLocci, C., Chicconi, E., & Antonucci, R. (2024). Current Uses of Bromelain in Children: A Narrative Review. Children, 11(3), 377. https://doi.org/10.3390/children11030377