Antiplatelet Effect of Melatonin through Breastfeeding: A Pediatric Case Report
Abstract
1. Introduction
2. Case Report
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Acuña-Castroviejo, D.; Escames, G.; Venegas, C.; Díaz-Casado, M.E.; Lima-Cabello, E.; López, L.C.; Rosales-Corral, S.; Tan, D.-X. Extrapineal melatonin: Sources, regulation, and potential functions. Cell. Mol. Life Sci. CMLS 2014, 71, 2997–3025. [Google Scholar] [CrossRef] [PubMed]
- Claustrat, B.; Brun, J.; Chazot, G. The basic physiology and pathophysiology of melatonin. Sleep Med. Rev. 2005, 9, 11–24. [Google Scholar] [CrossRef]
- Dash, S.K.E.D. Melatonin elevates intracellular free calcium in human platelets by inositol 1,4,5-trisphosphate independent mechanism. FEBS Lett. 2011, 585, 2345–2351. [Google Scholar] [CrossRef]
- Rios, E.R.V.; Venâncio, E.T.; Rocha, N.F.M.; Woods, D.J.; Vasconcelos, S.; Macedo, D.; de Sousa, F.C.F.; de França Fonteles, M.M. Melatonin: Pharmacological aspects and clinical trends. Int. J. Neurosci. 2010, 120, 583–590. [Google Scholar] [CrossRef] [PubMed]
- Carrillo-Vico, A.; Lardone, P.J.; Alvarez-Sánchez, N.; Rodríguez-Rodríguez, A.; Guerrero, J.M. Melatonin: Buffering the immune system. Int. J. Mol. Sci. 2013, 14, 8638–8683. [Google Scholar] [CrossRef] [PubMed]
- Reiter, R.J.; Tan, D.-X.; Fuentes-Broto, L. Melatonin: A multitasking molecule. Prog. Brain Res. 2010, 181, 127–151. [Google Scholar] [CrossRef]
- Girish, K.S.; Paul, M.; Thushara, R.M.; Hemshekhar, M.; Sundaram, M.S.; Rangappa, K.S.; Kemparaju, K. Melatonin elevates apoptosis in human platelets via ROS mediated mitochondrial damage. Biochem. Biophys. Res. Commun. 2013, 438, 198–204. [Google Scholar] [CrossRef]
- Slominski, R.M.; Reiter, R.J.; Schlabritz-Loutsevitch, N.; Ostrom, R.S.; Slominski, A.T. Melatonin membrane receptors in peripheral tissues: Distribution and functions. Mol. Cell. Endocrinol. 2012, 351, 152–166. [Google Scholar] [CrossRef]
- Cardinali, D.P.; Del Zar, M.M.; Vacas, M.I. The effects of melatonin in human platelets. Acta Physiol. Pharmacol. Ther. Latinoam. Organo Asoc. Latinoam. Cienc. Fisiol. Asoc. Latinoam. Farmacol. 1993, 43, 1–13. [Google Scholar]
- Brzezinski, A. Melatonin in humans. N. Engl. J. Med. 1997, 336, 186–195. [Google Scholar] [CrossRef]
- McCarthy, R.; Jungheim, E.S.; Fay, J.C.; Bates, K.; Herzog, E.D.; England, S.K. Riding the Rhythm of Melatonin Through Pregnancy to Deliver on Time. Front. Endocrinol. 2019, 10, 616. [Google Scholar] [CrossRef] [PubMed]
- Mirmiran, M.; Maas, Y.G.H.; Ariagno, R.L. Development of fetal and neonatal sleep and circadian rhythms. Sleep Med. Rev. 2003, 7, 321–334. [Google Scholar] [CrossRef] [PubMed]
- Aparici-Gonzalo, S.; Carrasco-García, Á.; Gombert, M.; Carrasco-Luna, J.; Pin-Arboledas, G.; Codoñer-Franch, P. Melatonin Content of Human Milk: The Effect of Mode of Delivery. Breastfeed. Med. Off. J. Acad. Breastfeed. Med. 2020, 15, 589–594. [Google Scholar] [CrossRef] [PubMed]
- Voiculescu, S.E.; Zygouropoulos, N.; Zahiu, C.D.; Zagrean, A.M. Role of melatonin in embryo fetal development. J. Med. Life 2014, 7, 488–492. [Google Scholar] [PubMed]
- McKenna, H.; Reiss, I.K.M. The case for a chronobiological approach to neonatal care. Early Hum. Dev. 2018, 126, 1–5. [Google Scholar] [CrossRef] [PubMed]
- Lewandowski, A.J.; Augustine, D.; Lamata, P.; Davis, E.F.; Lazdam, M.; Francis, J.; McCormick, K.; Wilkinson, A.R.; Singhal, A.; Lucas, A.; et al. Preterm heart in adult life: Cardiovascular magnetic resonance reveals distinct differences in left ventricular mass, geometry, and function. Circulation 2013, 127, 197–206. [Google Scholar] [CrossRef] [PubMed]
- Qin, Y.; Shi, W.; Zhuang, J.; Liu, Y.; Tang, L.; Bu, J.; Sun, J. Variations in melatonin levels in preterm and term human breast milk during the first month after delivery. Sci. Rep. 2019, 9, 17984. [Google Scholar] [CrossRef]
- Haynes, R.L.; Frelinger, A.L., 3rd; Giles, E.K.; Goldstein, R.D.; Tran, H.; Kozakewich, H.P.; Haas, E.A.; Gerrits, A.J.; Mena, O.J.; Trachtenberg, F.L.; et al. High serum serotonin in sudden infant death syndrome. Proc. Natl. Acad. Sci. USA 2017, 114, 7695–7700. [Google Scholar] [CrossRef]
- Sturner, W.Q.; Lynch, H.J.; Deng, M.H.; Gleason, R.E.; Wurtman, R.J. Melatonin concentrations in the sudden infant death syndrome. Forensic Sci. Int. 1990, 45, 171–180. [Google Scholar] [CrossRef]
- Merchant, N.M.; Azzopardi, D.V.; Hawwa, A.F.; McElnay, J.C.; Middleton, B.; Arendt, J.; Arichi, T.; Gressens, P.; Edwards, A.D. Pharmacokinetics of melatonin in preterm infants. Br. J. Clin. Pharmacol. 2013, 76, 725–733. [Google Scholar] [CrossRef]
- Kennaway, D.J. Potential safety issues in the use of the hormone melatonin in paediatrics. J. Paediatr. Child Health 2015, 51, 584–589. [Google Scholar] [CrossRef] [PubMed]
- Muñoz-Hoyos, A.; Rodriguez-Cabezas, T.; Molina-Carballo, A.; Martinez-Sempere, J.J.; Ruiz-Cosano, C.; Acuña-Castroviejo, D. Melatonin concentration in the umbilical artery and vein in human preterm and term neonates and neonates with acute fetal distress. J. Pineal Res. 1992, 13, 184–191. [Google Scholar] [CrossRef] [PubMed]
- Muñoz-Hoyos, A.; Jaldo-Alba, F.; Molina-Carballo, A.; Rodríguez-Cabezas, T.; Molina-Font, J.A.; Acuña-Castroviejo, D. Absence of plasma melatonin circadian rhythm during the first 72 hours of life in human infants. J. Clin. Endocrinol. Metab. 1993, 77, 699–703. [Google Scholar] [CrossRef] [PubMed]
- Sánchez-Barceló, E.J.; Mediavilla, M.D.; Reiter, R.J. Clinical uses of melatonin in pediatrics. Int. J. Pediatr. 2011, 2011, 892624. [Google Scholar] [CrossRef] [PubMed]
- Illnerová, H.; Buresová, M.; Presl, J. Melatonin rhythm in human milk. J. Clin. Endocrinol. Metab. 1993, 77, 838–841. [Google Scholar] [CrossRef] [PubMed][Green Version]
- Andersen, L.P.H.; Gögenur, I.; Rosenberg, J.; Reiter, R.J. The Safety of Melatonin in Humans. Clin. Drug Investig. 2016, 36, 169–175. [Google Scholar] [CrossRef]
- Bishop-Freeman, S.C.; Young, K.A.; Labay, L.M.; Beuhler, M.C.; Hudson, J.S. Melatonin Supplementation in Undetermined Pediatric Deaths. J. Anal. Toxicol. 2022, 46, 808–816. [Google Scholar] [CrossRef]
- DeMuro, R.L.; Nafziger, A.N.; Blask, D.E.; Menhinick, A.M.; Bertino, J.S. The absolute bioavailability of oral melatonin. J. Clin. Pharmacol. 2000, 40, 781–784. [Google Scholar] [CrossRef]
- Vacas, M.I.; Del Zar, M.M.; Martinuzzo, M.; Cardinali, D.P. Binding sites for [3H]-melatonin in human platelets. J. Pineal Res. 1992, 13, 60–65. [Google Scholar] [CrossRef]
- Pandi-Perumal, S.R.; BaHammam, A.S.; Ojike, N.I.; Akinseye, O.A.; Kendzerska, T.; Buttoo, K.; Dhandapany, P.S.; Brown, G.M.; Cardinali, D.P. Melatonin and Human Cardiovascular Disease. J. Cardiovasc. Pharmacol. Ther. 2017, 22, 122–132. [Google Scholar] [CrossRef]
- Codoñer-Franch, M.G.E.P. Melatonin in Early Nutrition: Long-Term Effects on Cardiovascular System. Int. J. Mol. Sci. 2021, 22, 6809. [Google Scholar] [CrossRef]
- Gimeno, M.F.; Landa, A.; Sterin-Speziale, N.; Cardinali, D.P.; Gimeno, A.L. Melatonin blocks in vitro generation of prostaglandin by the uterus and hypothalamus. Eur. J. Pharmacol. 1980, 62, 309–317. [Google Scholar] [CrossRef] [PubMed]
- Kornblihtt, L.I.; Finocchiaro, L.; Molinas, F.C. Inhibitory effect of melatonin on platelet activation induced by collagen and arachidonic acid. J. Pineal Res. 1993, 14, 184–191. [Google Scholar] [CrossRef] [PubMed]
- Böhm, A.; Lauko, V.; Dostalova, K.; Balanova, I.; Varga, I.; Bezak, B.; Jajcay, N.; Moravcik, R.; Lazurova, L.; Slezak, P.; et al. In-vitro antiplatelet effect of melatonin in healthy individuals and patients with type 2 diabetes mellitus. J. Endocrinol. Investig. 2023, 46, 2493–2500. [Google Scholar] [CrossRef] [PubMed]
- Del Zar, M.M.; Martinuzzo, M.; Falcón, C.; Cardinali, D.P.; Carreras, L.O.; Vacas, M.I. Inhibition of human platelet aggregation and thromboxane-B2 production by melatonin: Evidence for a diurnal variation. J. Clin. Endocrinol. Metab. 1990, 70, 246–251. [Google Scholar] [CrossRef]
- Shohrati, M.; Mohammadi, A.; Najafi, A.; Sharifzadeh, M.; Sharifnia, H.; Abdollahi, M.; Salesi, M.; Sahebnasagh, A.; Mojtahedzadeh, M. Evaluation of the Effects of Melatonin Supplementation on Coagulation in Patients with Haemorrhagic Stroke; A Randomized, Double-Blind, Controlled Trial. Front. Emerg. Med. 2021, 5. [Google Scholar] [CrossRef]
- Andrew, M.; Vegh, P.; Johnston, M.; Bowker, J.; Ofosu, F.; Mitchell, L. Maturation of the hemostatic system during childhood. Blood 1992, 80, 1998–2005. [Google Scholar] [CrossRef]
- Kremers, R.M.W.; Wagenvoord, R.J.; de Laat, H.B.; Monagle, P.; Hemker, H.C.; Ignjatovic, V. Low paediatric thrombin generation is caused by an attenuation of prothrombin conversion. Thromb. Haemost. 2016, 115, 1090–1100. [Google Scholar] [CrossRef]
- Andrew, M.; Schmidt, B.; Mitchell, L.; Paes, B.; Ofosu, F. Thrombin generation in newborn plasma is critically dependent on the concentration of prothrombin. Thromb. Haemost. 1990, 63, 27–30. [Google Scholar] [CrossRef]
- Del Vecchio, A.; Latini, G.; Henry, E.; Christensen, R.D. Template bleeding times of 240 neonates born at 24 to 41 weeks gestation. J. Perinatol. Off. J. Calif. Perinat. Assoc. 2008, 28, 427–431. [Google Scholar] [CrossRef]
- Livnat, T.; Barg, A.A.; Levy-Mendelovich, S.; Kenet, G. Rare bleeding disorders-old diseases in the era of novel options for therapy. Blood Cells. Mol. Dis. 2017, 67, 63–68. [Google Scholar] [CrossRef] [PubMed]
- Wirtz, P.H.; Bärtschi, C.; Spillmann, M.; Ehlert, U.; von Känel, R. Effect of oral melatonin on the procoagulant response to acute psychosocial stress in healthy men: A randomized placebo-controlled study. J. Pineal Res. 2008, 44, 358–365. [Google Scholar] [CrossRef] [PubMed]
- Wirtz, P.H.; Spillmann, M.; Bärtschi, C.; Ehlert, U.; von Känel, R. Oral melatonin reduces blood coagulation activity: A placebo-controlled study in healthy young men. J. Pineal Res. 2008, 44, 127–133. [Google Scholar] [CrossRef] [PubMed]
- Sánchez-Barceló, E.J.; Mediavilla, M.D.; Tan, D.X.; Reiter, R.J. Clinical uses of melatonin: Evaluation of human trials. Curr. Med. Chem. 2010, 17, 2070–2095. [Google Scholar] [CrossRef]
- Amer, M.R.; Cipriano, G.C.; Venci, J.V.; Gandhi, M.A. Safety of Popular Herbal Supplements in Lactating Women. J. Hum. Lact. Off. J. Int. Lact. Consult. Assoc. 2015, 31, 348–353. [Google Scholar] [CrossRef]
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Iavarone, S.; Massoud, M.; Di Felice, G.; Pulcinelli, F.; Rapini, N.; Luciani, M. Antiplatelet Effect of Melatonin through Breastfeeding: A Pediatric Case Report. Children 2023, 10, 1839. https://doi.org/10.3390/children10121839
Iavarone S, Massoud M, Di Felice G, Pulcinelli F, Rapini N, Luciani M. Antiplatelet Effect of Melatonin through Breastfeeding: A Pediatric Case Report. Children. 2023; 10(12):1839. https://doi.org/10.3390/children10121839
Chicago/Turabian StyleIavarone, Sonia, Michela Massoud, Giovina Di Felice, Fabio Pulcinelli, Novella Rapini, and Matteo Luciani. 2023. "Antiplatelet Effect of Melatonin through Breastfeeding: A Pediatric Case Report" Children 10, no. 12: 1839. https://doi.org/10.3390/children10121839
APA StyleIavarone, S., Massoud, M., Di Felice, G., Pulcinelli, F., Rapini, N., & Luciani, M. (2023). Antiplatelet Effect of Melatonin through Breastfeeding: A Pediatric Case Report. Children, 10(12), 1839. https://doi.org/10.3390/children10121839