Pattern of Primary Resistance of Helicobacter pylori to Clarithromycin among Pediatric Patients from North-Eastern Romania
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristics | Variables | Number of Patients | % |
---|---|---|---|
Sex | Female | 60 | 71.5% |
Male | 24 | 28.5% | |
Age | 6–9 years | 10 | 11.9% |
10–14 years | 32 | 38.1% | |
15–17 years | 42 | 50% | |
Place of residence | Urban | 30 | 35.7% |
Rural | 54 | 64.3% | |
H. pylori * resistance | Resistance | 35 | 41.6% |
Non-resistance | 49 | 58.4% |
Characteristics | Resistant to CLR * | Non-Resistant to CLR * | p | |||
---|---|---|---|---|---|---|
n | % | n | % | |||
Sex | Female | 28 | 80.0 | 32 | 65.3 | 0.145 |
Male | 7 | 20.0 | 17 | 34.7 | ||
Age | 6–9 years | 3 | 8.6 | 7 | 14.3 | 0.868 |
10–14 years | 15 | 42.9 | 17 | 34.7 | ||
15–17 years | 17 | 48.6 | 25 | 51.0 | ||
Clinical symptoms | Epigastric pain | 25 | 71.4 | 42 | 85.7 | 0.819 |
Abdominal recurrent pain | 8 | 22.9 | 4 | 8.2 | ||
Vomiting | 10 | 28.6 | 12 | 24.5 | ||
Refractory anemia | 3 | 8.6 | 1 | 2.0 | ||
Other | 2 | 5.7 | 5 | 10.2 |
Characteristics | Non-Resistant to CLR | Resistant to CLR | p | |||
---|---|---|---|---|---|---|
n | % | n | % | |||
Sex | Female | 32 | 65.3 | 28 | 80.0 | 0.063 |
Male | 17 | 34.7 | 7 | 20.0 | ||
Age | 6–9 years | 7 | 14.3 | 3 | 8.6 | 0.058 |
10–14 years | 17 | 34.7 | 15 | 42.9 | ||
15–17 years | 25 | 51.0 | 17 | 48.6 | ||
Environment | Urban | 17 | 34.7 | 13 | 37.1 | 0.082 |
Rural | 32 | 65.3 | 22 | 62.9 | ||
Living conditions | 1 pers/room | 16 | 32.6 | 6 | 17.1 | 0.075 |
2 pers/room | 22 | 44.9 | 17 | 48.6 | ||
≥3 pers/room | 11 | 22.5 | 12 | 34.3 | ||
History of antibiotic therapy | CLR | 43 | 87.8 | 34 | 97.1 | 0.046 |
MTZ | 8 | 16.3 | 6 | 17.1 | ||
AMX | 7 | 14.3 | 4 | 11.4 | ||
AMC | 27 | 55.1 | 19 | 54.3 | ||
Other | 8 | 16.3 | 12 | 34.3 | ||
Cannot remember | 1 | 2.0 | 0 | 0.0 | ||
Clinical symptoms | Epigastric pain | 42 | 85.7 | 25 | 71.4 | 0.048 |
Abdominal recurrent pain | 4 | 8.2 | 8 | 22.9 | ||
Vomiting | 12 | 24.5 | 10 | 28.6 | ||
Refractory anemia | 1 | 2.0 | 3 | 8.6 | ||
Other | 5 | 10.2 | 2 | 5.7 | ||
Endoscopic pattern | Nodular | 31 | 63.3 | 21 | 60.0 | 0.078 |
Erosive | 6 | 12.2 | 5 | 14.3 | ||
Hyperemic | 15 | 30.6 | 11 | 31.4 | ||
Snakeskin | 18 | 36.7 | 15 | 42.9 |
Characteristics | None | Mild | Moderate | Severe | p | ||||
---|---|---|---|---|---|---|---|---|---|
n | % | n | % | n | % | n | % | ||
Chronic Inflammation | - | - | 17 | 20.2 | 56 | 66.6 | 11 | 13.1 | 0.072 |
Neutrophilic Infiltrate | 15 | 17.9 | 28 | 33.3 | 34 | 40.5 | 7 | 8.3 | 0.062 |
Atrophy | 84 | 100 | - | - | - | - | - | - | - |
Intestinal Metaplasia | 84 | 100 | - | - | - | - | - | - | - |
H. pylori Density | 1 | 1.2 | 44 | 52.4 | 27 | 32.1 | 12 | 14.3 | 0.045 * |
Sydney System | Age | Sex | History of Antibiotic Therapy | Endoscopic Pattern | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
CLR | MTZ | AMX | AMC | Nodular | Erosive | Hyper Emic | Snake Skin | |||||
Chronic Inflammation | None | CC | −0.069 | 0.086 | 0.033 | −0.049 | −0.045 | −0.133 | −0.140 | −0.043 | 0.164 | −0.088 |
p-value | 0.53 | 0.44 | 0.76 | 0.66 | 0.69 | 0.23 | 0.20 | 0.70 | 0.14 | 0.42 | ||
Mild | CC | 0.096 | −0.203 | 0.037 | 0.027 | 0.062 | −0.094 | 0.006 | −0.009 | 0.069 | −0.142 | |
p-value | 0.39 | 0.06 | 0.74 | 0.81 | 0.58 | 0.39 | 0.96 | 0.94 | 0.53 | 0.20 | ||
Moderate | CC | −0.056 | 0.196 | −0.030 | −0.158 | 0.000 | 0.034 | 0.017 | 0.050 | −0.073 | 0.155 | |
p-value | 0.61 | 0.07 | 0.78 | 0.15 | 1.00 | 0.76 | 0.88 | 0.65 | 0.51 | 0.16 | ||
Severe | CC | −0.011 | −0.065 | −0.011 | 0.205 | −0.058 | 0.104 | 0.014 | −0.046 | −0.031 | −0.023 | |
p-value | 0.92 | 0.56 | 0.92 | 0.06 | 0.60 | 0.34 | 0.90 | 0.68 | 0.78 | 0.83 | ||
Neutrophilic Infiltrate | None | CC | −0.069 | 0.012 | 0.033 | −0.049 | −0.045 | 0.091 | 0.086 | −0.043 | −0.073 | −0.088 |
p-value | 0.53 | 0.91 | 0.76 | 0.66 | 0.67 | 0.41 | 0.44 | 0.70 | 0.51 | 0.42 | ||
Mild | CC | 0.073 | 0.083 | 0.023 | 0.034 | −0.062 | −0.056 | 0.015 | 0.111 | −0.130 | 0.125 | |
p-value | 0.51 | 0.45 | 0.83 | 0.76 | 0.57 | 0.61 | 0.89 | 0.32 | 0.24 | 0.26 | ||
Moderate | CC | −0.38 | −0.001 | 0.073 | −0.174 | 0.079 | 0.136 | 0.098 | −0.104 | 0.025 | −0.067 | |
p-value | 0.73 | 0.99 | 0.51 | 0.11 | 0.47 | 0.21 | 0.38 | 0.34 | 0.82 | 0.54 | ||
Severe | CC | 0.00 | −0.171 | −0.065 | 0.212 | 0.000 | −0.015 | −0.030 | −0.117 | 0.078 | −0.066 | |
p-value | 1.0 | 0.12 | 0.56 | 0.05 | 1.00 | 0.89 | 0.79 | 0.29 | 0.48 | 0.55 | ||
H. pylori Density | None | - | - | - | - | - | - | - | - | - | - | |
Mild | CC | −0.015 | 0.296 | 0.050 | 0.053 | −0.078 | 0.117 | 0.019 | −0.115 | −0.119 | 0.054 | |
p-value | 0.89 | 0.01 * | 0.65 | 0.63 | 0.48 | 0.29 | 0.87 | 0.30 | 0.28 | 0.63 | ||
Moderate | CC | 0.185 | −0.252 | −0.069 | 0.034 | 0.083 | −0.108 | −0.142 | 0.035 | 0.091 | −0.032 | |
p-value | 0.09 * | 0.02 * | 0.53 | 0.76 | 0.45 | 0.33 | 0.20 | 0.75 | 0.41 | 0.77 | ||
Severe | CC | −0.198 | −0.087 | 0.129 | −0.103 | 0.013 | −0.049 | 0.132 | 0.029 | 0.070 | −0.075 | |
p-value | 0.07 | 0.43 | 0.001 * | 0.66 | 0.69 | 0.41 | 0.009 * | 0.79 | 0.53 | 0.50 |
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Rosu, O.-M.; Gimiga, N.; Popescu, R.; Ioniuc, I.; Rusu, C.D.; Clipa, T.; Florea, D.-M.; Pleșca, D.-A.; Nemtoi, A.; Tataranu, E.; et al. Pattern of Primary Resistance of Helicobacter pylori to Clarithromycin among Pediatric Patients from North-Eastern Romania. Children 2023, 10, 1752. https://doi.org/10.3390/children10111752
Rosu O-M, Gimiga N, Popescu R, Ioniuc I, Rusu CD, Clipa T, Florea D-M, Pleșca D-A, Nemtoi A, Tataranu E, et al. Pattern of Primary Resistance of Helicobacter pylori to Clarithromycin among Pediatric Patients from North-Eastern Romania. Children. 2023; 10(11):1752. https://doi.org/10.3390/children10111752
Chicago/Turabian StyleRosu, Oana-Maria, Nicoleta Gimiga, Roxana Popescu, Ileana Ioniuc, Carmen Daniela Rusu, Tatiana Clipa, Diana-Maria Florea, Doina-Anca Pleșca, Alexandru Nemtoi, Elena Tataranu, and et al. 2023. "Pattern of Primary Resistance of Helicobacter pylori to Clarithromycin among Pediatric Patients from North-Eastern Romania" Children 10, no. 11: 1752. https://doi.org/10.3390/children10111752
APA StyleRosu, O.-M., Gimiga, N., Popescu, R., Ioniuc, I., Rusu, C. D., Clipa, T., Florea, D.-M., Pleșca, D.-A., Nemtoi, A., Tataranu, E., Stefanescu, G., & Diaconescu, S. (2023). Pattern of Primary Resistance of Helicobacter pylori to Clarithromycin among Pediatric Patients from North-Eastern Romania. Children, 10(11), 1752. https://doi.org/10.3390/children10111752