Atopic Dermatitis in Italian Pre-School Children: Literature Review of Epidemiological Data with a Focus on Disease Prevalence and Severity
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Source | Period | Area | Study Design | Study Population | Type of Diagnosis | Notes |
---|---|---|---|---|---|---|
Agosti et al., 2003 [10] | 1994–2000 | Milan-Varese | Birth cohort | Population-based (hospital newborns) | Arata Criteria | |
Cantarutti et al., 2015 [15] | 2006–2012 | Italy | Retrospective cohort | Primary care patients | Diagnosis of AD registered by a paediatrician | |
Fortes et al., 2019 [16] | NR | Rome | Birth cohort | Population-based (hospital newborns) | UK Diagnostic Criteria | Study not focused on AD incidence/prevalence, but it reports such results |
Fuertes et al., 2020 [17] | 2003–2008 | Rome (within an international study) | Birth cohort | Population-based (hospital newborns) | Based on 2 ISAAC questions (itchy rash and localisation, in the previous 12 months) | Study not focused on AD incidence/prevalence, but it reports such results |
Indinnimeo et al., 2016 [11] | NR | Rome | Cross-sectional survey | Population-based | AD in the last 12 months (ISAAC), self-reported by parents | |
Parazzini et al., 2014 [12] | 2007–2010 | Bergamo | Birth cohort | Population-based (hospital newborns) | UK Working Party diagnostic criteria and diagnosis by a paediatrician or dermatologist, reported by parents | Study not focused on AD incidence/prevalence, but it reports such results |
Parmes et al., 2020 [18] | 2009–2014 | Italy (within an international study) | Birth cohort | Population-based (hospital newborns) | Itchy rash that comes and goes or diagnosis of AD by a clinician | Study not focused on AD incidence/prevalence, but it reports such results |
Peroni et al., 2008 [13] | NR | Verona | Cross-sectional survey | Population-based |
| |
Silverberg et al., 2021 [9] | 2018–2019 | Italy | Web survey | Population-based |
| |
Stazi et al., 2002 [19] | 1993–1994 | Basilicata | Cross-sectional survey | Population-based | AD diagnosed by a clinician |
Source | N | Age Considered | Lifetime Prevalence | Period (12 mo) Prevalence | Notes |
---|---|---|---|---|---|
Agosti et al., 2003 [10] | 98 | 0–6 years | 33.7% over the entire 6-year period | NR | Data for full-term children. Results of children with very low birth weight were excluded |
Cantarutti et al., 2015 [15] | ≈55,000 (0 y: 10,000; 1–4 y: 45,000) |
| NR |
| Year-by-year results, for the period from 2006 to 2012 Approximate results, as they were derived from two figures |
Fortes et al., 2019 [16] | 344 | 0–6 years | 7.8% over the entire 6-year period | NR | Among the diagnostic criteria is ‘onset of AD before the age of 2 years’ |
Fuertes et al., 2020 [17] | 581 | 4 years | NR | 13.3% | Only data from the Italian GASPII cohort were reported |
Indinnimeo et al., 2016 [11] | 494 | 3–5 | NR | 11.8% | |
Parazzini et al., 2014 [12] | 796 | 0–1 year |
| NR | |
Parmes et al., 2020 [18] | 274 | 0–3 years | 17.8% over the entire 3-year period | NR | Other Italian cohorts in the study were excluded because most of the children were of school age |
Peroni et al., 2008 [13] | 1402 | 3–5 | 20.9% over the entire 3–5 year period (based on symptoms) |
| |
Silverberg et al., 2021 [9] | 1547 | 6 months to <6 years | NR |
| The study reports information on the severity of AD, based on PGA and POEM |
Stazi et al., 2002 [19] | 201 | 3 months to 5 years | 8.0% | NR |
All Studies | Only Recent Studies (≥2010) | |||||||
---|---|---|---|---|---|---|---|---|
Epidemiological Measurement | No. of Studies | No. of Measures | Range | Median | No. of Studies | No. of Measures | Range | Median |
Lifetime prevalence | 6 | 6 | 7.8–33.7% | 19.3% | 2 | 2 | 7.8–17.8% | 12.8% |
Period prevalence, 12 months | 5 | 8 b | 4.0–42.2% b | 14.3% | 3 | 5 b | 4.0–42.2% b | 11.8% |
Incidence rate (/100 py) | 1 | 2 b | 2.5–9.0 b | 5.7 | 1 | 2 b | 2.5–9.0 b | 5.7 |
Source | Area | Study Design | No. Enrolled | Severity Measurement | Indicator/Level | Result |
---|---|---|---|---|---|---|
Ruggiero et al., 2012 [20] | Italy, 16 regions involved | Survey of family paediatricians | 437 | Simple question on the case history of each paediatrician | % of cases evaluated as: | |
| 68.9% | |||||
| 23.3% | |||||
| 7.8% | |||||
Galli et al., 2020 [21] | Italy, 9 cities | Cross-sectional, paediatric or allergy centre patients | 206 at pre-school age | SCORAD | % of cases with SCORAD: | |
| 64% | |||||
| 25% | |||||
| 11% | |||||
Silverberg et al., 2021 [9] | Italy (within an international study conducted in 18 countries) | Cross-sectional, web-survey | 1547, of which 132 with AD diagnosed by a clinician | POEM and PtGA | % of cases with POEM: | |
| 52.2% | |||||
| 38.7% | |||||
| 8.4% | |||||
% of cases with PtGA: | ||||||
| 54.2% | |||||
| 34.3% | |||||
| 10.8% |
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Neri, I.; Galeone, C.; Pelucchi, C.; Ronci, G.; Matruglio, P.; Pedone, M.P.; Galli, E. Atopic Dermatitis in Italian Pre-School Children: Literature Review of Epidemiological Data with a Focus on Disease Prevalence and Severity. Children 2023, 10, 1629. https://doi.org/10.3390/children10101629
Neri I, Galeone C, Pelucchi C, Ronci G, Matruglio P, Pedone MP, Galli E. Atopic Dermatitis in Italian Pre-School Children: Literature Review of Epidemiological Data with a Focus on Disease Prevalence and Severity. Children. 2023; 10(10):1629. https://doi.org/10.3390/children10101629
Chicago/Turabian StyleNeri, Iria, Carlotta Galeone, Claudio Pelucchi, Gianluca Ronci, Paolo Matruglio, Maria Paola Pedone, and Elena Galli. 2023. "Atopic Dermatitis in Italian Pre-School Children: Literature Review of Epidemiological Data with a Focus on Disease Prevalence and Severity" Children 10, no. 10: 1629. https://doi.org/10.3390/children10101629