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Article

Sex-Related Motor Deficits in the Tau-P301L Mouse Model

1
Institute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, Germany
2
Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany
3
Institute of Neuroscience and Medicine, Medical Imaging Physics (INM-4), Forschungszentrum Jülich, 52425 Jülich, Germany
4
JARA-Brain-Translational Medicine, JARA Institute Molecular Neuroscience and Neuroimaging, 52062 Aachen, Germany
5
Department of Neurology, RWTH Aachen University, 52062 Aachen, Germany
6
Department of Nuclear Medicine, RWTH Aachen University, 52062 Aachen, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Martina Perše
Biomedicines 2021, 9(9), 1160; https://doi.org/10.3390/biomedicines9091160
Received: 29 July 2021 / Revised: 31 August 2021 / Accepted: 1 September 2021 / Published: 4 September 2021
(This article belongs to the Special Issue Animal Models of Human Pathology: Revision, Relevance and Refinements)
The contribution of mouse models for basic and translational research at different levels is important to understand neurodegenerative diseases, including tauopathies, by studying the alterations in the corresponding mouse models in detail. Moreover, several studies demonstrated that pathological as well as behavioral changes are influenced by the sex. For this purpose, we performed an in-depth characterization of the behavioral alterations in the transgenic Tau-P301L mouse model. Sex-matched wild type and homozygous Tau-P301L mice were tested in a battery of behavioral tests at different ages. Tau-P301L male mice showed olfactory and motor deficits as well as increased Tau pathology, which was not observed in Tau-P301L female mice. Both Tau-P301L male and female mice had phenotypic alterations in the SHIRPA test battery and cognitive deficits in the novel object recognition test. This study demonstrated that Tau-P301L mice have phenotypic alterations, which are in line with the histological changes and with a sex-dependent performance in those tests. Summarized, the Tau-P301L mouse model shows phenotypic alterations due to the presence of neurofibrillary tangles in the brain. View Full-Text
Keywords: tauopathy; Tau-P301L mouse models; behavior; phosphorylated Tau; motor deficits; cognitive deficits; sex-related deficits tauopathy; Tau-P301L mouse models; behavior; phosphorylated Tau; motor deficits; cognitive deficits; sex-related deficits
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MDPI and ACS Style

Camargo, L.C.; Honold, D.; Bauer, R.; Shah, N.J.; Langen, K.-J.; Willbold, D.; Kutzsche, J.; Willuweit, A.; Schemmert, S. Sex-Related Motor Deficits in the Tau-P301L Mouse Model. Biomedicines 2021, 9, 1160. https://doi.org/10.3390/biomedicines9091160

AMA Style

Camargo LC, Honold D, Bauer R, Shah NJ, Langen K-J, Willbold D, Kutzsche J, Willuweit A, Schemmert S. Sex-Related Motor Deficits in the Tau-P301L Mouse Model. Biomedicines. 2021; 9(9):1160. https://doi.org/10.3390/biomedicines9091160

Chicago/Turabian Style

Camargo, Luana C., Dominik Honold, Robert Bauer, N. J. Shah, Karl-Josef Langen, Dieter Willbold, Janine Kutzsche, Antje Willuweit, and Sarah Schemmert. 2021. "Sex-Related Motor Deficits in the Tau-P301L Mouse Model" Biomedicines 9, no. 9: 1160. https://doi.org/10.3390/biomedicines9091160

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