Early Life Stress and Metabolic Plasticity of Brain Cells: Impact on Neurogenesis and Angiogenesis
Abstract
:1. Introduction
2. Developmental Aspects of Brain Metabolism and Effects of ELS
3. Neurogenesis and Cerebral Angiogenesis: Search for a Common Regulator of Metabolic Reprogramming
4. Conclusions and Further Prospects: Strategies Aimed to Restore Metabolic Plasticity of Brain Cells for Efficient Neurogenesis and Angiogenesis
Author Contributions
Funding
Conflicts of Interest
References
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Type of Cells | Metabolic Characteristics | References |
---|---|---|
Neurons | Oxidative phosphorylation (OXPHOS) dominates. Perisynaptic localization of mitochondria. Under stress and aging, they redistribute mitochondria in the cell and demonstrate impairment in glycose utilization and decline in mitochondrial function. Poorly utilize fatty acids. | [53,54,55,56] |
Astrocytes | Glycolysis dominates. They support the metabolism of neurons with lactate. Capable of depositing the glycogen. Mitochondrial activity determines the efficiency of glutamate uptake. Serve as donors of mitochondria when neurons are damaged. | [57,58,59,60] |
Oligodendrocytes | Myelination is under the control of OXPHOS (to a greater extent) and glycolysis, at the end of the myelination program, glycolysis dominates, and lactate maintains axonal vitality. | [61,62,63] |
Microglia | Resting microglia uses OXPHOS, activated microglia uses glycolysis. Microglia activation is accompanied by mitochondrial fragmentation. | [64,65,66] |
BMECs | Have a higher content of mitochondria than endothelial cells in other tissues. Angiogenesis is accompanied by increased glycolysis and OXPHOS, fatty acid oxidation. Disturbances in mitochondrial dynamics are characteristic of damage to the BBB. Various reactive oxygen species (ROS)-generating enzymes are expressed. | [67,68,69,70,71] |
Pericytes | Glycolysis dominates; however, these cells might donate mitochondria for damaged perivascular astroglia. | [72] |
NSCs/NPCs | Self-maintenance and proliferation of NSCs/NPCs require glycolysis, oxidation of fatty acids. Differentiation is accompanied by the prevalence of OXPHOS, and significant changes in the shape of mitochondria from fragmented to elongated. Able to deliver functional mitochondria to target cells. Aging NSCs/NPCs demonstrate lower oxidative metabolism. | [73,74,75,76,77,78] |
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Salmina, A.B.; Gorina, Y.V.; Komleva, Y.K.; Panina, Y.A.; Malinovskaya, N.A.; Lopatina, O.L. Early Life Stress and Metabolic Plasticity of Brain Cells: Impact on Neurogenesis and Angiogenesis. Biomedicines 2021, 9, 1092. https://doi.org/10.3390/biomedicines9091092
Salmina AB, Gorina YV, Komleva YK, Panina YA, Malinovskaya NA, Lopatina OL. Early Life Stress and Metabolic Plasticity of Brain Cells: Impact on Neurogenesis and Angiogenesis. Biomedicines. 2021; 9(9):1092. https://doi.org/10.3390/biomedicines9091092
Chicago/Turabian StyleSalmina, Alla B., Yana V. Gorina, Yulia K. Komleva, Yulia A. Panina, Natalia A. Malinovskaya, and Olga L. Lopatina. 2021. "Early Life Stress and Metabolic Plasticity of Brain Cells: Impact on Neurogenesis and Angiogenesis" Biomedicines 9, no. 9: 1092. https://doi.org/10.3390/biomedicines9091092