Strategies to Improve Bone Healing: Innovative Surgical Implants Meet Nano-/Micro-Topography of Bone Scaffolds
Abstract
:1. Introduction
2. Mechanical Environment
2.1. Mechanical Environment on the Bone
2.2. Mechanical Environment and Fracture Healing
2.3. Bone-Implant Construct Stiffness and “Dynamic” Osteosynthesis
2.4. Variable Fixation Technology
3. Bone Scaffolds Guiding Osteoinduction—An Interplay of Micro- and Nano-Topography
3.1. Natural Bone Architecture and Topography
3.2. Nanotopographical Cues of Scffolds Drive Osteoinduction and Possess Anti-Bacterial Activities
3.3. Linking the Nano- and the Microscale: Bone Scaffolds Combining an Optimal Microtopography for Vascularization and Stem Cell Migration with Nanotopographical Osteoinductive Cues
3.4. Bone Scaffolds Combining Topographical Cues with Stem Cell-Loading
3.5. Dynamizing Scaffold Design: Magnetic Scaffolds for Bone Regeneration
4. Conclusions
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Wähnert, D.; Greiner, J.; Brianza, S.; Kaltschmidt, C.; Vordemvenne, T.; Kaltschmidt, B. Strategies to Improve Bone Healing: Innovative Surgical Implants Meet Nano-/Micro-Topography of Bone Scaffolds. Biomedicines 2021, 9, 746. https://doi.org/10.3390/biomedicines9070746
Wähnert D, Greiner J, Brianza S, Kaltschmidt C, Vordemvenne T, Kaltschmidt B. Strategies to Improve Bone Healing: Innovative Surgical Implants Meet Nano-/Micro-Topography of Bone Scaffolds. Biomedicines. 2021; 9(7):746. https://doi.org/10.3390/biomedicines9070746
Chicago/Turabian StyleWähnert, Dirk, Johannes Greiner, Stefano Brianza, Christian Kaltschmidt, Thomas Vordemvenne, and Barbara Kaltschmidt. 2021. "Strategies to Improve Bone Healing: Innovative Surgical Implants Meet Nano-/Micro-Topography of Bone Scaffolds" Biomedicines 9, no. 7: 746. https://doi.org/10.3390/biomedicines9070746