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Energy, Entropy and Quantum Tunneling of Protons and Electrons in Brain Mitochondria: Relation to Mitochondrial Impairment in Aging-Related Human Brain Diseases and Therapeutic Measures
 
 
Review
Peer-Review Record

Mind the Gap: Mitochondria and the Endoplasmic Reticulum in Neurodegenerative Diseases

Biomedicines 2021, 9(2), 227; https://doi.org/10.3390/biomedicines9020227
by Nuno Santos Leal * and Luís Miguel Martins *
Reviewer 1: Anonymous
Reviewer 2:
Biomedicines 2021, 9(2), 227; https://doi.org/10.3390/biomedicines9020227
Submission received: 2 February 2021 / Revised: 17 February 2021 / Accepted: 18 February 2021 / Published: 23 February 2021
(This article belongs to the Special Issue Mitochondria and Brain Disease)

Round 1

Reviewer 1 Report

At the beginning of the text, there is a description of the symbiotic evolution of mitochondria, which I thought was very interesting to read. 
As regards the relationship between neurodegenerative diseases such as AD and MERCS, the important points are outlined in an easy-to-understand manner. I think this manuscript is easy to understand even for readers who are not experts in the field.

Author Response

We appreciate the reviewer's comments.

Accordingly, we have not changed the text nor the figures in the manuscript

Reviewer 2 Report

A very thorough review on the background and evolution in our understanding of MERCS. The implications with respect to neurodegenerative diseases as well as potential pharmacological manipulation makes the review particularly grounded and relevant. 

Author Response

We appreciate the reviewer's comments.

Accordingly, we have not changed the text nor the figures in the manuscript

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