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Article

Skin Wound Healing of the Adult Newt, Cynops pyrrhogaster: A Unique Re-Epithelialization and Scarless Model

1
Department of Plastic and Reconstructive Surgery, Keio University, Shinanomachi 35, Tokyo 160-8582, Japan
2
Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto 390-8621, Japan
3
Faculty of Life and Environmental Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba 305-8572, Japan
4
Department of Pathology, The Nippon Dental University School of Life Dentistry at Tokyo, Fujimi 1-9-20, Tokyo 102-8159, Japan
5
Graduate School of Engineering, Utsunomiya University, Yoto 7-1-2, Utsunomiya 321-8585, Japan
*
Authors to whom correspondence should be addressed.
Academic Editor: Marc Ekker
Biomedicines 2021, 9(12), 1892; https://doi.org/10.3390/biomedicines9121892
Received: 26 November 2021 / Revised: 10 December 2021 / Accepted: 11 December 2021 / Published: 13 December 2021
In surgical and cosmetic studies, scarless regeneration is an ideal method to heal skin wounds. To study the technologies that enable scarless skin wound healing in medicine, animal models are useful. However, four-limbed vertebrates, including humans, generally lose their competency of scarless regeneration as they transit to their terrestrial life-stages through metamorphosis, hatching or birth. Therefore, animals that serve as a model for postnatal humans must be an exception to this rule, such as the newt. Here, we evaluated the adult newt in detail for the first time. Using a Japanese fire-bellied newt, Cynops pyrrhogaster, we excised the full-thickness skin at various locations on the body, and surveyed their re-epithelialization, granulation or dermal fibrosis, and recovery of texture and appendages as well as color (hue, tone and pattern) for more than two years. We found that the skin of adult newts eventually regenerated exceptionally well through unique processes of re-epithelialization and the absence of fibrotic scar formation, except for the dorsal-lateral to ventral skin whose unique color patterns never recovered. Color pattern is species-specific. Consequently, the adult C. pyrrhogaster provides an ideal model system for studies aimed at perfect skin wound healing and regeneration in postnatal humans. View Full-Text
Keywords: newt; skin regeneration; re-epithelialization; scarless; color pattern newt; skin regeneration; re-epithelialization; scarless; color pattern
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MDPI and ACS Style

Ishii, T.; Takashimizu, I.; Casco-Robles, M.M.; Taya, Y.; Yuzuriha, S.; Toyama, F.; Maruo, F.; Kishi, K.; Chiba, C. Skin Wound Healing of the Adult Newt, Cynops pyrrhogaster: A Unique Re-Epithelialization and Scarless Model. Biomedicines 2021, 9, 1892. https://doi.org/10.3390/biomedicines9121892

AMA Style

Ishii T, Takashimizu I, Casco-Robles MM, Taya Y, Yuzuriha S, Toyama F, Maruo F, Kishi K, Chiba C. Skin Wound Healing of the Adult Newt, Cynops pyrrhogaster: A Unique Re-Epithelialization and Scarless Model. Biomedicines. 2021; 9(12):1892. https://doi.org/10.3390/biomedicines9121892

Chicago/Turabian Style

Ishii, Tatsuyuki, Ikkei Takashimizu, Martin Miguel Casco-Robles, Yuji Taya, Shunsuke Yuzuriha, Fubito Toyama, Fumiaki Maruo, Kazuo Kishi, and Chikafumi Chiba. 2021. "Skin Wound Healing of the Adult Newt, Cynops pyrrhogaster: A Unique Re-Epithelialization and Scarless Model" Biomedicines 9, no. 12: 1892. https://doi.org/10.3390/biomedicines9121892

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