Next Article in Journal
Antiangiogenic Properties of Axitinib versus Sorafenib Following Sunitinib Resistance in Human Endothelial Cells—A View towards Second Line Renal Cell Carcinoma Treatment
Next Article in Special Issue
Current Treatments and New Possible Complementary Therapies for Epithelial Ovarian Cancer
Previous Article in Journal
Lupus Vasculitis: An Overview
Previous Article in Special Issue
Circulating Exosomal miRNAs as Biomarkers in Epithelial Ovarian Cancer
Article

Biological Planning of Radiation Dose Based on In Vivo Dosimetry for Postoperative Vaginal-Cuff HDR Interventional Radiotherapy (Brachytherapy)

1
Radiation Oncology Department, University of Lübeck/UKSH-CL, 23562 Lübeck, Germany
2
National Cancer Institute (NCI), Radiation Oncology Department, Cairo University, Giza 12613, Egypt
3
UOC Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, Italy
4
Gemelli-INTERACTS, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
*
Author to whom correspondence should be addressed.
Equal contribution.
Academic Editor: Naomi Nakayama
Biomedicines 2021, 9(11), 1629; https://doi.org/10.3390/biomedicines9111629
Received: 25 September 2021 / Revised: 28 October 2021 / Accepted: 4 November 2021 / Published: 6 November 2021
(This article belongs to the Special Issue Mechanisms and Novel Therapeutic Approaches for Gynecologic Cancer)
(1) Background: Postoperative vaginal-cuff HDR interventional radiotherapy (brachytherapy) is a standard treatment in early-stage endometrial cancer. This study reports the effect of in vivo dosimetry-based biological planning for two different fractionation schedules on the treatment-related toxicities. (2) Methods: 121 patients were treated. Group A (82) received 21 Gy in three fractions. Group B (39) received 20 Gy in four fractions. The dose was prescribed at a 5 mm depth or to the applicator surface according to the distance between the applicator and the rectum. In vivo dosimetry measured the dose of the rectum and/or urinary bladder. With a high measured dose, the dose prescription was changed from a 5 mm depth to the applicator surface. (3) Results: The median age was 66 years with 58.8 months mean follow-up. The dose prescription was changed in 20.7% of group A and in 41% of group B. Most toxicities were grade 1–2. Acute urinary toxicities were significantly higher in group A. The rates of acute and late urinary toxicities were significantly higher with a mean bladder dose/fraction of >2.5 Gy and a total bladder dose of >7.5 Gy. One patient had a vaginal recurrence. (4) Conclusions: Both schedules have excellent local control and acceptable rates of toxicities. Using in vivo dosimetry-based biological planning yielded an acceptable dose to the bladder and rectum. View Full-Text
Keywords: interventional radiotherapy; vaginal-cuff brachytherapy; HDR brachytherapy; in vivo dosimetry; endometrial cancer; biological planning interventional radiotherapy; vaginal-cuff brachytherapy; HDR brachytherapy; in vivo dosimetry; endometrial cancer; biological planning
Show Figures

Figure 1

MDPI and ACS Style

Soror, T.; Chafii, R.; Lancellotta, V.; Tagliaferri, L.; Kovács, G. Biological Planning of Radiation Dose Based on In Vivo Dosimetry for Postoperative Vaginal-Cuff HDR Interventional Radiotherapy (Brachytherapy). Biomedicines 2021, 9, 1629. https://doi.org/10.3390/biomedicines9111629

AMA Style

Soror T, Chafii R, Lancellotta V, Tagliaferri L, Kovács G. Biological Planning of Radiation Dose Based on In Vivo Dosimetry for Postoperative Vaginal-Cuff HDR Interventional Radiotherapy (Brachytherapy). Biomedicines. 2021; 9(11):1629. https://doi.org/10.3390/biomedicines9111629

Chicago/Turabian Style

Soror, Tamer, Ramin Chafii, Valentina Lancellotta, Luca Tagliaferri, and György Kovács. 2021. "Biological Planning of Radiation Dose Based on In Vivo Dosimetry for Postoperative Vaginal-Cuff HDR Interventional Radiotherapy (Brachytherapy)" Biomedicines 9, no. 11: 1629. https://doi.org/10.3390/biomedicines9111629

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop