Oral Mucositis in Cancer and Potential Use of Omega-3 Free Fatty Acids in Its Management: A Review
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School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland 1142, New Zealand
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Department of Stomatology, A.C. Camargo Cancer Center, FO-USP, São Paulo 01525-001, Brazil
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School of Public Health and Interdisciplinary Studies, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland 1142, New Zealand
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College of Food Engineering and Nutrition Sciences, Shaanxi Normal University, Xi’an 710119, China
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College of Food Science and Technology, Nanchang University, Nanchang 330031, China
6
Maurice Wilkins Centre for Molecular Discovery, Auckland 1010, New Zealand
*
Author to whom correspondence should be addressed.
Academic Editors: Amirata Saei Dibavar and Yoshihiro Abiko
Biomedicines 2021, 9(11), 1531; https://doi.org/10.3390/biomedicines9111531
Received: 15 August 2021
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Revised: 18 October 2021
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Accepted: 19 October 2021
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Published: 25 October 2021
(This article belongs to the Special Issue Biomedicine from the Sea)
Oral mucositis (OM) is a painful condition caused by chemotherapeutic or radiotherapeutic cancer treatments, occurring in patients with different tumour characteristics and locations. OM greatly impacts a patient’s quality of life and cancer recovery. Current OM management strategies are not providing sufficient prevention and treatment; new approaches to injury management are needed. Studies on the benefit of omega-3 free fatty acids (FFA) in human health have increased significantly in recent years. FFA properties have been studied extensively, including their potential therapeutic use in inflammatory conditions. However, omega-3 FFA’s use as a supplementary treatment for OM has not been clinically tested. Preliminary evidence suggests that utilising FFA to manage OM could be a useful strategy for lesion management, assisting with healthy oral mucosa recovery. This review will describe the incidence, risk factors, biology of OM and the current treatment strategies, leading to a discussion of the utility of omega-3 FFA as a novel therapeutic agent for OM.
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Keywords:
oral mucositis; inflammation; polyunsaturated fatty acids; omega-3 fatty acids; omega-6 fatty acids; cancer; prostaglandins; leukotrienes; interleukins; cytokines
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MDPI and ACS Style
Lessa, R.C.; Alves, F.d.A.; Fortunati, E.; Lu, J. Oral Mucositis in Cancer and Potential Use of Omega-3 Free Fatty Acids in Its Management: A Review. Biomedicines 2021, 9, 1531. https://doi.org/10.3390/biomedicines9111531
AMA Style
Lessa RC, Alves FdA, Fortunati E, Lu J. Oral Mucositis in Cancer and Potential Use of Omega-3 Free Fatty Acids in Its Management: A Review. Biomedicines. 2021; 9(11):1531. https://doi.org/10.3390/biomedicines9111531
Chicago/Turabian StyleLessa, Roberta C., Fabio d.A. Alves, Erika Fortunati, and Jun Lu. 2021. "Oral Mucositis in Cancer and Potential Use of Omega-3 Free Fatty Acids in Its Management: A Review" Biomedicines 9, no. 11: 1531. https://doi.org/10.3390/biomedicines9111531
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