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Biomedicines
Volume 9
Issue 10
10.3390/biomedicines9101489
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Article

Pulsed Radiofrequency Upregulates Serotonin Transporters and Alleviates Neuropathic Pain-Induced Depression in a Spared Nerve Injury Rat Model

by
Kuo-Hsing Ma
1,†,
Cheng-Yi Cheng
2,†,
Wei-Hung Chan
3,
Shih-Yu Chen
3,
Li-Ting Kao
4,5,
Chun-Sung Sung
6,7,
Dueng-Yuan Hueng
8 and
Chun-Chang Yeh
3,9,*
1
Department of Biology and Anatomy, National Defense Medical Center, Taipei 115, Taiwan
2
Department of Nuclear Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 115, Taiwan
3
Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei 115, Taiwan
4
Department of Pharmacy Practice, Tri-Service General Hospital, National Defense Medical Center, Taipei 115, Taiwan
5
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 115, Taiwan
6
Department of Anesthesiology, Taipei Veterans General Hospital, Taipei 112, Taiwan
7
School of Medicine, National Yang-Ming Chiao-Tung University, Taipei 112, Taiwan
8
Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 115, Taiwan
9
Integrated Pain Management Center, Tri-Service General Hospital, National Defense Medical Center, Taipei 115, Taiwan
*
Author to whom correspondence should be addressed.
†
Kuo-Hsing Ma and Cheng-Yi Cheng contributed equally to this work.
Biomedicines 2021, 9(10), 1489; https://doi.org/10.3390/biomedicines9101489
Submission received: 27 September 2021 / Revised: 10 October 2021 / Accepted: 14 October 2021 / Published: 16 October 2021
(This article belongs to the Section Cell Biology and Pathology)
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Abstract

Neuropathic pain (NP) is difficult to treat due to complex pathophysiological mechanisms. Pulsed radiofrequency (RRF) has been used widely with neuromodulation effect in refractory chronic pain treatment. A recent study found that PRF treatment may decrease chronic pain-related anxiety-depressant symptoms in patients, even though the mechanisms are unclear. Additionally, accumulated evidence has shown serotonin uptake is correlated with various neuropsychiatric diseases. Therefore, we investigated the effects and underlying mechanisms of PRF on depression-like behaviors, resulting from spared nerve injury (SNI)-induced NP. We examined the indexes of mechanical allodynia, cold allodynia, depression-like behavior, and blood cytokines by dynamic plantar aesthesiometry, acetone spray test, forced swimming test, and ProcartaPlex multiplex immunoassays in male Wistar rats, respectively. Serotonin transporters (SERTs) in rat brains were examined by using 4-[18F]-ADAM/PET imaging. We found that specific uptake ratios (SURs) of SERTs were significantly decreased in the brain regions of the thalamus and striatum in rats with SNI-induced NP and depression-like behaviors. Additionally, the decrease in SERT density was correlated with the development of a depression-like behavior indicated by the forced swimming test results and pronounced IL-6 cytokines. Moreover, we demonstrated that PRF application could modulate the descending serotoninergic pathway to relieve pain and depression behaviors.
Keywords: pulsed radiofrequency; neuropathic pain; depression-like behaviors; positron emission tomography; serotonin transporters pulsed radiofrequency; neuropathic pain; depression-like behaviors; positron emission tomography; serotonin transporters

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MDPI and ACS Style

Ma, K.-H.; Cheng, C.-Y.; Chan, W.-H.; Chen, S.-Y.; Kao, L.-T.; Sung, C.-S.; Hueng, D.-Y.; Yeh, C.-C. Pulsed Radiofrequency Upregulates Serotonin Transporters and Alleviates Neuropathic Pain-Induced Depression in a Spared Nerve Injury Rat Model. Biomedicines 2021, 9, 1489. https://doi.org/10.3390/biomedicines9101489

AMA Style

Ma K-H, Cheng C-Y, Chan W-H, Chen S-Y, Kao L-T, Sung C-S, Hueng D-Y, Yeh C-C. Pulsed Radiofrequency Upregulates Serotonin Transporters and Alleviates Neuropathic Pain-Induced Depression in a Spared Nerve Injury Rat Model. Biomedicines. 2021; 9(10):1489. https://doi.org/10.3390/biomedicines9101489

Chicago/Turabian Style

Ma, Kuo-Hsing, Cheng-Yi Cheng, Wei-Hung Chan, Shih-Yu Chen, Li-Ting Kao, Chun-Sung Sung, Dueng-Yuan Hueng, and Chun-Chang Yeh. 2021. "Pulsed Radiofrequency Upregulates Serotonin Transporters and Alleviates Neuropathic Pain-Induced Depression in a Spared Nerve Injury Rat Model" Biomedicines 9, no. 10: 1489. https://doi.org/10.3390/biomedicines9101489

APA Style

Ma, K.-H., Cheng, C.-Y., Chan, W.-H., Chen, S.-Y., Kao, L.-T., Sung, C.-S., Hueng, D.-Y., & Yeh, C.-C. (2021). Pulsed Radiofrequency Upregulates Serotonin Transporters and Alleviates Neuropathic Pain-Induced Depression in a Spared Nerve Injury Rat Model. Biomedicines, 9(10), 1489. https://doi.org/10.3390/biomedicines9101489

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