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Volume 9
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10.3390/biomedicines9101458
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Article

Differential Capability of Clinically Employed Dermal Regeneration Scaffolds to Support Vascularization for Tissue Bioengineering

by
Chiara Agostinis
1,
Mariagiulia Spazzapan
2,
Roman Vuerich
2,3,
Andrea Balduit
2,*,
Chiara Stocco
4,
Alessandro Mangogna
1,
Giuseppe Ricci
1,4,
Giovanni Papa
4,
Serena Zacchigna
3,4 and
Roberta Bulla
2
1
Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) “Burlo Garofolo”, 34137 Trieste, Italy
2
Department of Life Sciences, University of Trieste, 34127 Trieste, Italy
3
International Centre for Genetic Engineering and Biotechnology, Cardiovascular Biology Laboratory, 34149 Trieste, Italy
4
Department of Medical, Surgical and Health Sciences, University of Trieste, 34100 Trieste, Italy
*
Author to whom correspondence should be addressed.
Biomedicines 2021, 9(10), 1458; https://doi.org/10.3390/biomedicines9101458
Submission received: 9 September 2021 / Revised: 27 September 2021 / Accepted: 11 October 2021 / Published: 13 October 2021
(This article belongs to the Special Issue Biomedical Potential of Stem Cells in Skin Regeneration and Wound Healing)
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Abstract

The loss of skin integrity has always represented a major challenge for clinicians dealing with dermal defects, such as ulcers (diabetic, vascular and chronic), postoncologic resections (i.e., radical vulvectomy) or dermatologic disorders. The introduction in recent decades of acellular dermal matrices (ADMs) supporting the repair and restoration of skin functionality represented a significant step toward achieving clean wound repair before performing skin grafts. Hard-to-heal ulcers generally depend on local ischemia and nonadequate vascularization. In this context, one possible innovative approach could be the prevascularization of matrices with vessel-forming cells (inosculation). This paper presents a comparative analysis of the most widely used dermal templates, i.e., Integra® Bilayer Matrix Wound Dressing, PELNAC®, PriMatrix® Dermal Repair Scaffold, Endoform® Natural Dermal Template, and Myriad Matrix®, testing their ability to be colonized by human adult dermal microvascular endothelial cells (ADMECs) and to induce and support angiogenesis in vitro and in vivo. By in vitro studies, we demonstrated that Integra® and PELNAC® possess superior pro-adhesive and pro-angiogenetic properties. Animal models allowed us to demonstrate the ability of preseeded ADMECs on Integra® to promote the engraftment, integration and vascularization of ADMs at the site of application.
Keywords: endothelial cells; acellular dermal matrices (ADMs); chronic wounds; wound healing; angiogenesis endothelial cells; acellular dermal matrices (ADMs); chronic wounds; wound healing; angiogenesis

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MDPI and ACS Style

Agostinis, C.; Spazzapan, M.; Vuerich, R.; Balduit, A.; Stocco, C.; Mangogna, A.; Ricci, G.; Papa, G.; Zacchigna, S.; Bulla, R. Differential Capability of Clinically Employed Dermal Regeneration Scaffolds to Support Vascularization for Tissue Bioengineering. Biomedicines 2021, 9, 1458. https://doi.org/10.3390/biomedicines9101458

AMA Style

Agostinis C, Spazzapan M, Vuerich R, Balduit A, Stocco C, Mangogna A, Ricci G, Papa G, Zacchigna S, Bulla R. Differential Capability of Clinically Employed Dermal Regeneration Scaffolds to Support Vascularization for Tissue Bioengineering. Biomedicines. 2021; 9(10):1458. https://doi.org/10.3390/biomedicines9101458

Chicago/Turabian Style

Agostinis, Chiara, Mariagiulia Spazzapan, Roman Vuerich, Andrea Balduit, Chiara Stocco, Alessandro Mangogna, Giuseppe Ricci, Giovanni Papa, Serena Zacchigna, and Roberta Bulla. 2021. "Differential Capability of Clinically Employed Dermal Regeneration Scaffolds to Support Vascularization for Tissue Bioengineering" Biomedicines 9, no. 10: 1458. https://doi.org/10.3390/biomedicines9101458

APA Style

Agostinis, C., Spazzapan, M., Vuerich, R., Balduit, A., Stocco, C., Mangogna, A., Ricci, G., Papa, G., Zacchigna, S., & Bulla, R. (2021). Differential Capability of Clinically Employed Dermal Regeneration Scaffolds to Support Vascularization for Tissue Bioengineering. Biomedicines, 9(10), 1458. https://doi.org/10.3390/biomedicines9101458

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