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Article

A Gadolinium DO3A Amide m-Phenyl Boronic Acid MRI Probe for Targeted Imaging of Sialated Solid Tumors

1
Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
2
Biomedical Translation Research Center, Academia Sinica, Taipei 115, Taiwan
*
Author to whom correspondence should be addressed.
Those authors were contributed equally.
Academic Editor: Paul Rösch
Biomedicines 2021, 9(10), 1459; https://doi.org/10.3390/biomedicines9101459
Received: 22 September 2021 / Revised: 7 October 2021 / Accepted: 12 October 2021 / Published: 13 October 2021
(This article belongs to the Section Biomedical Materials and Nanomedicine)
We developed a new probe, Gd-DO3A-Am-PBA, for imaging tumors. Our results showed active targeting of Gd-DO3A-Am-PBA to sialic acid (SA) moieties, with increased cellular labeling in vitro and enhanced tumor accumulation and retention in vivo, compared to the commercial Gadovist. The effectiveness of our newly synthesized probe lies in its adequate retention phase, which is expected to provide a suitable time window for tumor diagnosis and a faster renal clearance, which will reduce toxicity risks when translated to clinics. Hence, this study can be extended to other tumor types that express SA on their surface. Targeting and MR imaging of any type of tumors can also be achieved by conjugating the newly synthesized contrast agent with specific antibodies. This study thus opens new avenues for drug delivery and tumor diagnosis via imaging. View Full-Text
Keywords: MRI; contrast agent; CA; DOTA; PBA; SA MRI; contrast agent; CA; DOTA; PBA; SA
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MDPI and ACS Style

Rajan, C.; Seema, J.; Chen, Y.-W.; Chen, T.-C.; Lin, M.-H.; Lin, C.-H.; Hwang, D.W.-H. A Gadolinium DO3A Amide m-Phenyl Boronic Acid MRI Probe for Targeted Imaging of Sialated Solid Tumors. Biomedicines 2021, 9, 1459. https://doi.org/10.3390/biomedicines9101459

AMA Style

Rajan C, Seema J, Chen Y-W, Chen T-C, Lin M-H, Lin C-H, Hwang DW-H. A Gadolinium DO3A Amide m-Phenyl Boronic Acid MRI Probe for Targeted Imaging of Sialated Solid Tumors. Biomedicines. 2021; 9(10):1459. https://doi.org/10.3390/biomedicines9101459

Chicago/Turabian Style

Rajan, Christu, Jaya Seema, Yu-Wen Chen, Tsai-Chen Chen, Ming-Huang Lin, Chia-Huei Lin, and Dennis W.-H. Hwang. 2021. "A Gadolinium DO3A Amide m-Phenyl Boronic Acid MRI Probe for Targeted Imaging of Sialated Solid Tumors" Biomedicines 9, no. 10: 1459. https://doi.org/10.3390/biomedicines9101459

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