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Elements of Immunoglobulin E Network Associate with Aortic Valve Area in Patients with Acquired Aortic Stenosis

1
Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, Medical Faculty, Philipps University Marburg, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, 35043 Marburg, Germany
2
Krakow Center for Medical Research and Technology, John Paul II Hospital, 31-202 Krakow, Poland
3
Department of Internal Medicine, Jagiellonian University Medical College, 31-066 Krakow, Poland
4
Department of Hematology, Jagiellonian University Medical College, 31-501 Krakow, Poland
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Atopy Research Center, Juntendo University School of Medicine, Tokyo 113-8421, Japan
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Laboratory of Molecular Biology and Immunology, Department of Biological Science and Technology, Tokyo University of Science, Tokyo 125-8585, Japan
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Institute of Cardiology, Jagiellonian University Medical College, 31-202 Krakow, Poland
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Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, 30-705 Krakow, Poland
*
Author to whom correspondence should be addressed.
These first authors contributed equally to this work.
These last authors contributed equally to this work.
Biomedicines 2021, 9(1), 23; https://doi.org/10.3390/biomedicines9010023
Received: 29 November 2020 / Revised: 23 December 2020 / Accepted: 26 December 2020 / Published: 31 December 2020
(This article belongs to the Special Issue Calcific Aortic Valve Disease and Aortic Stenosis)
Allergic mechanisms are likely involved in atherosclerosis and its clinical presentations, such as coronary artery disease (CAD). It has been previously reported that CAD severity associates with serum levels of immunoglobulin E (IgE), the molecule that, along with its high-affinity receptor (FcԑRI), plays a central role in allergic reactions. Considering multiple pathophysiological similarities between atherosclerosis and acquired aortic (valve) stenosis (AS), we speculated that allergic pathways could also contribute to the AS mechanisms and grading. To validate this hypothesis, we first checked whether total serum IgE levels associate with echocardiographic markers of AS severity. Having found a positive correlation between serum IgE and aortic valve area (AVA), we further speculated that also total IgE-determining genetic polymorphisms in FCER1A, a locus encoding an allergen-biding FcԑRI subunit, are related to acquired AS severity. Indeed, the major allele of rs2251746 polymorphism, known to associate with higher IgE levels, turned out to correlate with larger AVA, a marker of less severe AS. Our findings surprisingly suggest a protective role of IgE pathways against AS progression. IgE-mediated protective mechanisms in AS require further investigations. View Full-Text
Keywords: aortic valve area (AVA); aortic (valve) stenosis (AS; AVS); FcԑRI α-subunit (FcԑRIα) gene (FCER1A); (genetic) polymorphism; high-affinity IgE receptor (FcԑRI); immunoglobulin E (IgE) aortic valve area (AVA); aortic (valve) stenosis (AS; AVS); FcԑRI α-subunit (FcԑRIα) gene (FCER1A); (genetic) polymorphism; high-affinity IgE receptor (FcԑRI); immunoglobulin E (IgE)
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MDPI and ACS Style

Potaczek, D.P.; Przytulska-Szczerbik, A.; Bazan-Socha, S.; Jurczyszyn, A.; Okumura, K.; Nishiyama, C.; Undas, A.; Wypasek, E. Elements of Immunoglobulin E Network Associate with Aortic Valve Area in Patients with Acquired Aortic Stenosis. Biomedicines 2021, 9, 23. https://doi.org/10.3390/biomedicines9010023

AMA Style

Potaczek DP, Przytulska-Szczerbik A, Bazan-Socha S, Jurczyszyn A, Okumura K, Nishiyama C, Undas A, Wypasek E. Elements of Immunoglobulin E Network Associate with Aortic Valve Area in Patients with Acquired Aortic Stenosis. Biomedicines. 2021; 9(1):23. https://doi.org/10.3390/biomedicines9010023

Chicago/Turabian Style

Potaczek, Daniel P., Aleksandra Przytulska-Szczerbik, Stanisława Bazan-Socha, Artur Jurczyszyn, Ko Okumura, Chiharu Nishiyama, Anetta Undas, and Ewa Wypasek. 2021. "Elements of Immunoglobulin E Network Associate with Aortic Valve Area in Patients with Acquired Aortic Stenosis" Biomedicines 9, no. 1: 23. https://doi.org/10.3390/biomedicines9010023

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