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Mass-Spectrometry Based Proteome Comparison of Extracellular Vesicle Isolation Methods: Comparison of ME-kit, Size-Exclusion Chromatography, and High-Speed Centrifugation

Extracellular Vesicles in Acute Stroke Diagnostics

Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, DK-8000 Aarhus, Denmark
Sino-Danish Center for Education and Research, Beijing 101400, China
Sino-Danish Center for Education and Research, DK-8000 Aarhus, Denmark
Department of Neurology, Aarhus University Hospital, DK-8200 Aarhus, Denmark
Department of Clinical Medicine, Aarhus University, DK-8200 Aarhus, Denmark
Author to whom correspondence should be addressed.
Biomedicines 2020, 8(8), 248;
Received: 20 June 2020 / Revised: 16 July 2020 / Accepted: 20 July 2020 / Published: 28 July 2020
There is a large unmet need for fast and reliable diagnostics in several diseases. One such disease is stroke, where the efficacy of modern reperfusion therapies is highly time-dependent. Diagnosis of stroke and treatment initiation should be performed as soon as possible, and preferably before arrival at the stroke center. In recent years, several potential blood biomarkers for stroke have been evaluated, but without success. In this review, we will go into detail on the possibility of utilizing extracellular vesicles (EVs) released into the blood as novel biomarkers for stroke diagnostics. EVs are known to reflect the immediate state of the secreting cells and to be able to cross the blood–brain barrier, thus making them attractive as diagnostic biomarkers of brain diseases. Indeed, several studies have reported EV markers that enable differentiation between stroke patients and controls and, to a lesser extent, the ability to correctly classify the different stroke types. Most of the studies rely on the use of sophisticated and time-consuming methods to quantify specific subpopulations of the nanosized EVs. As these methods cannot be easily implemented in a rapid point of care (POC) test, technical developments followed by prospective clinical studies are needed. View Full-Text
Keywords: stroke; circulating biomarkers; extracellular vesicles; diagnostics stroke; circulating biomarkers; extracellular vesicles; diagnostics
MDPI and ACS Style

Stenz, K.T.; Just, J.; Blauenfeldt, R.A.; Drasbek, K.R. Extracellular Vesicles in Acute Stroke Diagnostics. Biomedicines 2020, 8, 248.

AMA Style

Stenz KT, Just J, Blauenfeldt RA, Drasbek KR. Extracellular Vesicles in Acute Stroke Diagnostics. Biomedicines. 2020; 8(8):248.

Chicago/Turabian Style

Stenz, Katrine T., Jesper Just, Rolf A. Blauenfeldt, and Kim R. Drasbek. 2020. "Extracellular Vesicles in Acute Stroke Diagnostics" Biomedicines 8, no. 8: 248.

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