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Open AccessArticle

Characterization of the Antinociceptive Activity from Stevia serrata Cav

Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil
Institute of Natural Products Research, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil
School of Chemistry, Faculty of Chemical Sciences and Pharmacy, University of San Carlos of Guatemala, Guatemala 01012, Guatemala
Author to whom correspondence should be addressed.
Biomedicines 2020, 8(4), 79;
Received: 3 March 2020 / Revised: 31 March 2020 / Accepted: 31 March 2020 / Published: 7 April 2020
(This article belongs to the Special Issue Natural Medicine in Therapy)
Background: Stevia serrata Cav. (Asteraceae), widely found in Guatemala, is used to treat gastrointestinal problems. The aim of this study was to demonstrate the antinociceptive and anti-inflammatory effects of the essential oil (EO) and the mechanism of action. Methods: EO was tested in chemical (capsaicin- and glutamate-induced licking response) or thermal (hot plate) models of nociception at 10, 30 or 100 mg/kg doses. The mechanism of action was evaluated using two receptor antagonists (naloxone, atropine) and an enzyme inhibitor (L-NAME). The anti-hyperalgesic effect was evaluated using carrageenan-induced nociception and evaluated in the hot plate. Results: All three doses of EO reduced licking response induced by glutamate, and higher doses reduced capsaicin-induced licking. EO also increased area under the curve, similar to the morphine-treated group. The antinociceptive effect induced by EO was reversed by pretreatment of mice with naloxone (1 mg/kg, ip), atropine (1 mg/kg, ip) or L-NAME (3 mg/kg, ip). EO also demonstrated an anti-hyperalgesic effect. The 100 mg/kg dose increased the latency time, even at 1 h after oral administration and this effect has been maintained until the 96th hour, post-administration. Conclusions: Our data suggest that essential oil of S. serrata presents an antinociceptive effect mediated, at least in part, through activation of opioid, cholinergic and nitrergic pathways. View Full-Text
Keywords: Stevia serrata; essential oil; inflammation; antinociception; pain Stevia serrata; essential oil; inflammation; antinociception; pain
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Cordeiro, M.S.; Simas, D.L.R.; Pérez-Sabino, J.F.; Mérida-Reyes, M.S.; Muñoz-Wug, M.A.; Oliva-Hernández, B.E.; da Silva, A.J.R.; Fernandes, P.D.; Giorno, T.B.S. Characterization of the Antinociceptive Activity from Stevia serrata Cav. Biomedicines 2020, 8, 79.

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