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Self-Assembling β-Glucan Nanomedicine for the Delivery of siRNA

School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea
Center for Biomaterials, Korea Institute of Science and Technology, Seoul 02792, Korea
BioScience Lab, Basic Research & Innovation Division, R&D Unit, AMOREPACIFIC, Yongin-si 17074, Korea
Department of Chemical Engineering, Hanyang University, Ansan-si 15588, Korea
School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457, Singapore
Author to whom correspondence should be addressed.
These authors contributed equally.
Biomedicines 2020, 8(11), 497;
Received: 19 September 2020 / Revised: 9 November 2020 / Accepted: 9 November 2020 / Published: 12 November 2020
(This article belongs to the Special Issue Hybrid Nanoplatforms for Theranostics Nanomedicine)
We aimed to design and manufacture a transporter capable of delivering small interfering RNAs (siRNAs) into the skin without causing any damage. β-glucans are unique chiral polysaccharides with well-defined immunological properties and supramolecular wrapping ability. However, the chiral properties of these polymers have hardly been applied in drug delivery systems. In this study, β-glucan nanoparticles were designed and manufactured to deliver genetic material to the target cells. The β-glucan molecules were self-assembled with an siRNA into nanoparticles of 300–400 nm in diameter via a conformational transition process, in order to construct a gene delivery system. The assembled gene nanocarriers were associated with high gene-loading ability. The expression and efficiency of siRNA were verified after its delivery via β-glucan. Our results provide evidence that β-glucan nanoparticles can be effectively used to deliver siRNA into the cells. View Full-Text
Keywords: beta-glucan; self-assembly; nanomedicine; siRNA; gene delivery beta-glucan; self-assembly; nanomedicine; siRNA; gene delivery
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MDPI and ACS Style

Lee, K.; Min, D.; Choi, Y.; Yoon, S.; Jang, J.; Hwang, J.; Jeon, H.; Cho, Y.W.; Choi, J. Self-Assembling β-Glucan Nanomedicine for the Delivery of siRNA. Biomedicines 2020, 8, 497.

AMA Style

Lee K, Min D, Choi Y, Yoon S, Jang J, Hwang J, Jeon H, Cho YW, Choi J. Self-Assembling β-Glucan Nanomedicine for the Delivery of siRNA. Biomedicines. 2020; 8(11):497.

Chicago/Turabian Style

Lee, Kyungwoo, Daejin Min, Yonghyun Choi, Semi Yoon, Jaehee Jang, Jangsun Hwang, Hojeong Jeon, Yong W. Cho, and Jonghoon Choi. 2020. "Self-Assembling β-Glucan Nanomedicine for the Delivery of siRNA" Biomedicines 8, no. 11: 497.

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