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Article

Self-Assembling β-Glucan Nanomedicine for the Delivery of siRNA

1
School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea
2
Center for Biomaterials, Korea Institute of Science and Technology, Seoul 02792, Korea
3
BioScience Lab, Basic Research & Innovation Division, R&D Unit, AMOREPACIFIC, Yongin-si 17074, Korea
4
Department of Chemical Engineering, Hanyang University, Ansan-si 15588, Korea
5
School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457, Singapore
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Biomedicines 2020, 8(11), 497; https://doi.org/10.3390/biomedicines8110497
Received: 19 September 2020 / Revised: 9 November 2020 / Accepted: 9 November 2020 / Published: 12 November 2020
(This article belongs to the Special Issue Hybrid Nanoplatforms for Theranostics Nanomedicine)
We aimed to design and manufacture a transporter capable of delivering small interfering RNAs (siRNAs) into the skin without causing any damage. β-glucans are unique chiral polysaccharides with well-defined immunological properties and supramolecular wrapping ability. However, the chiral properties of these polymers have hardly been applied in drug delivery systems. In this study, β-glucan nanoparticles were designed and manufactured to deliver genetic material to the target cells. The β-glucan molecules were self-assembled with an siRNA into nanoparticles of 300–400 nm in diameter via a conformational transition process, in order to construct a gene delivery system. The assembled gene nanocarriers were associated with high gene-loading ability. The expression and efficiency of siRNA were verified after its delivery via β-glucan. Our results provide evidence that β-glucan nanoparticles can be effectively used to deliver siRNA into the cells. View Full-Text
Keywords: beta-glucan; self-assembly; nanomedicine; siRNA; gene delivery beta-glucan; self-assembly; nanomedicine; siRNA; gene delivery
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MDPI and ACS Style

Lee, K.; Min, D.; Choi, Y.; Yoon, S.; Jang, J.; Hwang, J.; Jeon, H.; Cho, Y.W.; Choi, J. Self-Assembling β-Glucan Nanomedicine for the Delivery of siRNA. Biomedicines 2020, 8, 497. https://doi.org/10.3390/biomedicines8110497

AMA Style

Lee K, Min D, Choi Y, Yoon S, Jang J, Hwang J, Jeon H, Cho YW, Choi J. Self-Assembling β-Glucan Nanomedicine for the Delivery of siRNA. Biomedicines. 2020; 8(11):497. https://doi.org/10.3390/biomedicines8110497

Chicago/Turabian Style

Lee, Kyungwoo, Daejin Min, Yonghyun Choi, Semi Yoon, Jaehee Jang, Jangsun Hwang, Hojeong Jeon, Yong W. Cho, and Jonghoon Choi. 2020. "Self-Assembling β-Glucan Nanomedicine for the Delivery of siRNA" Biomedicines 8, no. 11: 497. https://doi.org/10.3390/biomedicines8110497

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