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Open AccessArticle

Antihyperlipidemic and Antioxidant Effects of Averrhoa Carambola Extract in High-Fat Diet-Fed Rats

1
Department of Medical Analysis, Princess Aisha Bint Al-Hussein College of Nursing and Medical Sciences, Al-Hussein Bin Talal University, Ma`an 71111, Jordan
2
Department of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia
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Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia
4
Department of Pharmacology and Toxicology, Virginia CommonWealth University, Richmond, VA 23284, USA
5
Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Pinang 11800, Malaysia
6
Physiology Division, Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt
*
Authors to whom correspondence should be addressed.
Biomedicines 2019, 7(3), 72; https://doi.org/10.3390/biomedicines7030072
Received: 1 September 2019 / Revised: 12 September 2019 / Accepted: 14 September 2019 / Published: 16 September 2019
(This article belongs to the Section Natural Compounds in Biomedicine)
The present study explored the antihyperlipidemic potential of a standardized methanolic extract of Averrhoa carambola (A. carambola) leaf (MEACL) in high-fat diet (HFD)-fed rats. The standardized MEACL was orally administered at different doses (250, 500, and 1000 mg/kg) to HFD-induced hyperlipidemic rats for five weeks. Serum lipid profile, body weight changes, body mass index (BMI), daily food intake, relative organ weight, and histology of the liver were evaluated. In addition, the effect of MEACL on HMG-CoA reductase and pancreatic lipase activities as well as hepatic and fecal lipids was demonstrated. MEACL supplementation reduced serum lipids in HFD-fed rats in a dose-dependent manner. Histopathological scores revealed that 1000 mg/kg MEACL restored the damage to liver tissue in hyperlipidemic rats. MEACL decreased the body mass index (BMI), atherogenic index, and hepatic cholesterol and triglycerides and increased fecal cholesterol and bile acids in HFD-fed rats. Also, MEACL ameliorated lipid peroxidation and improved antioxidant defenses in the liver of HFD-fed rats. Furthermore, HMG-CoA reductase and lipase were suppressed by MEACL. In conclusion, this study shows the potential effect of MEACL to ameliorate hyperlipidemia and oxidative stress in HFD-fed rats. It prevented hepatic lipid accumulation and exerted an inhibitory effect on HMG-CoA reductase and lipase. View Full-Text
Keywords: Averrhoa carambola; dyslipidemia; high-fat diet; HMG-CoA; oxidative stress Averrhoa carambola; dyslipidemia; high-fat diet; HMG-CoA; oxidative stress
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Aladaileh, S.H.; Saghir, S.A.M.; Murugesu, K.; Sadikun, A.; Ahmad, A.; Kaur, G.; Mahmoud, A.M.; Murugaiyah, V. Antihyperlipidemic and Antioxidant Effects of Averrhoa Carambola Extract in High-Fat Diet-Fed Rats. Biomedicines 2019, 7, 72.

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