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Biomedicines
Volume 7
Issue 3
10.3390/biomedicines7030052
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Article

Differential Roles of Dendritic Cells in Expanding CD4 T Cells in Sepsis

by
Samuel Darkwah
1,
Nodoka Nago
1,2,
Michael G. Appiah
1,
Phyoe Kyawe Myint
1,
Eiji Kawamoto
1,3,
Motomu Shimaoka
1 and
Eun Jeong Park
1,*
1
Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan
2
Department of Clinical Nutrition, Suzuka University of Medical Science, Suzuka, Mie 510-0293, Japan
3
Department of Emergency and Disaster Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan
*
Author to whom correspondence should be addressed.
Biomedicines 2019, 7(3), 52; https://doi.org/10.3390/biomedicines7030052
Received: 31 May 2019 / Revised: 12 July 2019 / Accepted: 15 July 2019 / Published: 18 July 2019
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Abstract

Sepsis is a systemically dysregulated inflammatory syndrome, in which dendritic cells (DCs) play a critical role in coordinating aberrant immunity. The aim of this study is to shed light on the differential roles played by systemic versus mucosal DCs in regulating immune responses in sepsis. We identified a differential impact of the systemic and mucosal DCs on proliferating allogenic CD4 T cells in a mouse model of sepsis. Despite the fact that the frequency of CD4 T cells was reduced in septic mice, septic mesenteric lymph node (MLN) DCs proved superior to septic spleen (SP) DCs in expanding allogeneic CD4 T cells. Moreover, septic MLN DCs markedly augmented the surface expression of MHC class II and CD40, as well as the messaging of interleukin-1β (IL-1β). Interestingly, IL-1β-treated CD4 T cells expanded in a dose-dependent manner, suggesting that this cytokine acts as a key mediator of MLN DCs in promoting septic inflammation. Thus, mucosal and systemic DCs were found to be functionally different in the way CD4 T cells respond during sepsis. Our study provides a molecular basis for DC activity, which can be differential in nature depending on location, whereby it induces septic inflammation or immune-paralysis. View Full-Text
Keywords: sepsis; spleen; mesenteric lymph nodes; dendritic cells; CD4 T cells; IL-1β sepsis; spleen; mesenteric lymph nodes; dendritic cells; CD4 T cells; IL-1β
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

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MDPI and ACS Style

Darkwah, S.; Nago, N.; Appiah, M.G.; Myint, P.K.; Kawamoto, E.; Shimaoka, M.; Park, E.J. Differential Roles of Dendritic Cells in Expanding CD4 T Cells in Sepsis. Biomedicines 2019, 7, 52. https://doi.org/10.3390/biomedicines7030052

AMA Style

Darkwah S, Nago N, Appiah MG, Myint PK, Kawamoto E, Shimaoka M, Park EJ. Differential Roles of Dendritic Cells in Expanding CD4 T Cells in Sepsis. Biomedicines. 2019; 7(3):52. https://doi.org/10.3390/biomedicines7030052

Chicago/Turabian Style

Darkwah, Samuel, Nodoka Nago, Michael G. Appiah, Phyoe K. Myint, Eiji Kawamoto, Motomu Shimaoka, and Eun J. Park 2019. "Differential Roles of Dendritic Cells in Expanding CD4 T Cells in Sepsis" Biomedicines 7, no. 3: 52. https://doi.org/10.3390/biomedicines7030052

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