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Comparative Evaluation of Endotoxin Activity Level and Various Biomarkers for Infection and Outcome of ICU-Admitted Patients

1
Division of Critical Care and Emergency Medicine, Tokyo Medical University Hachioji Medical Center, Tokyo 193-0998, Japan
2
Department of Anesthesiology, Tokyo Medical University Hachioji Medical Center, Tokyo 193-0998, Japan
*
Author to whom correspondence should be addressed.
Biomedicines 2019, 7(3), 47; https://doi.org/10.3390/biomedicines7030047
Received: 22 May 2019 / Revised: 27 June 2019 / Accepted: 27 June 2019 / Published: 29 June 2019
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Abstract

Here, we concurrently measured the endotoxin activity (EA) level and levels of multiple biomarkers in patient blood obtained within 24 h after being admitted into the intensive care unit (ICU) and analyzed whether there were links between these markers and their associations with patient conditions and outcomes. The EA levels highly correlated with disease severity and patient survival, and showed a significant positive association with levels of lactate, procalcitonin, presepsin, and interleukin-6. Notably, the EA level was the marker that most highly correlated with the results of blood culture, and the presepsin level was the marker most highly correlated with the survival outcome at 28 days. Thus, the optimal biomarker should be selected based on whether it will be used to discriminate the presence of an infection or to predict survival. View Full-Text
Keywords: blood endotoxin; endotoxin activity assay (EAA); procalcitonin (PCT); presepsin; interleukin (IL)-6; sepsis blood endotoxin; endotoxin activity assay (EAA); procalcitonin (PCT); presepsin; interleukin (IL)-6; sepsis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ikeda, T.; Kamohara, H.; Suda, S.; Nagura, T.; Tomino, M.; Sugi, M.; Wajima, Z. Comparative Evaluation of Endotoxin Activity Level and Various Biomarkers for Infection and Outcome of ICU-Admitted Patients. Biomedicines 2019, 7, 47.

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