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Biomedicines 2018, 6(3), 76; https://doi.org/10.3390/biomedicines6030076

Immune Profiling of Cancer Patients Treated with Immunotherapy: Advances and Challenges

1
Medical Oncology Unit, San Gerardo Hospital, 20900 Monza, Italy
2
Clinical Research Center, Division of Translational Medicine, Sidra Medicine, Doha PoBox 26999, Qatar
*
Author to whom correspondence should be addressed.
Received: 28 May 2018 / Revised: 23 June 2018 / Accepted: 25 June 2018 / Published: 2 July 2018
(This article belongs to the Special Issue Dissecting the Immunological Landscape of Human Malignancies)
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Abstract

The recent advances in immunotherapy and the availability of novel drugs to target the tumor microenvironment have dramatically changed the paradigm of cancer treatment. Nevertheless, a significant proportion of cancer patients are unresponsive or develop resistance to these treatments. With the aim to increase the clinical efficacy of immunotherapy, combinations of agents and standard therapies with complementary actions have been developed mostly on an empirical base, since their mechanisms of actions are not yet fully dissected. The characterization of immune responsiveness and its monitoring along with the treatment of cancer patients with immunotherapy can provide insights into the mechanisms of action of these therapeutic regimens and contribute to the optimization of patients’ stratification and of combination strategies and to the prediction of treatment-related toxicities. Thus far, none of the immunomonitoring strategies has been validated for routine clinical practice. Moreover, it is becoming clear that the genomic and molecular make-up of tumors and of the infiltrating immune system represent important determinants of the clinical responses to immunotherapy. This review provides an overview of different approaches for the immune profiling of cancer patients and discusses their advantages and limitations. Recent advances in genomic-based assays and in the identification of host genomic relationships with immune responses represent promising approaches to identify molecular determinants and biomarkers to improve the clinical efficacy of cancer immunotherapy.
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Keywords: immunotherapy; immune monitoring; T cell responses; soluble markers; genomic determinants immunotherapy; immune monitoring; T cell responses; soluble markers; genomic determinants
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Pilla, L.; Maccalli, C. Immune Profiling of Cancer Patients Treated with Immunotherapy: Advances and Challenges. Biomedicines 2018, 6, 76.

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