Next Article in Journal
The Local Atomic Structure of Colloidal Superparamagnetic Iron Oxide Nanoparticles for Theranostics in Oncology
Next Article in Special Issue
Stem-Like Signature Predicting Disease Progression in Early Stage Bladder Cancer. The Role of E2F3 and SOX4
Previous Article in Journal
Immune Profiling of Cancer Patients Treated with Immunotherapy: Advances and Challenges
Previous Article in Special Issue
Mammary Stem Cells and Breast Cancer Stem Cells: Molecular Connections and Clinical Implications
Open AccessReview

Breast Cancer Stem Cells

Department of Genetics and the Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Author to whom correspondence should be addressed.
Biomedicines 2018, 6(3), 77;
Received: 26 June 2018 / Revised: 13 July 2018 / Accepted: 14 July 2018 / Published: 17 July 2018
(This article belongs to the Special Issue Stem Cells and Cancer Therapeutics)
PDF [263 KB, uploaded 17 July 2018]


Breast cancer stem cells (BCSC) have been implicated in tumor initiation, progression, metastasis, recurrence, and resistance to therapy. The origins of BCSCs remain controversial due to tumor heterogeneity and the presence of such small side populations for study, but nonetheless, cell surface markers and their correlation with BCSC functionality continue to be identified. BCSCs are driven by persistent activation of developmental pathways, such as Notch, Wnt, Hippo, and Hedgehog and new treatment strategies that are aimed at these pathways are in preclinical and clinical development. View Full-Text
Keywords: breast cancer; stem cells; Notch; Wnt; Hedgehog; Hippo breast cancer; stem cells; Notch; Wnt; Hedgehog; Hippo

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Crabtree, J.S.; Miele, L. Breast Cancer Stem Cells. Biomedicines 2018, 6, 77.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Biomedicines EISSN 2227-9059 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top