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Biomedicines 2016, 4(3), 13;

Tumor-Associated Macrophages in Oncolytic Virotherapy: Friend or Foe?

Center for Childhood Cancer and Blood Diseases, Division of Hematology/Oncology/Blood and Marrow Transplant, Nationwide Children’s Hospital, The Ohio State University, Columbus, OH 43205, USA
Author to whom correspondence should be addressed.
Academic Editor: Zong Sheng Guo
Received: 21 May 2016 / Revised: 28 June 2016 / Accepted: 4 July 2016 / Published: 7 July 2016
(This article belongs to the Special Issue Oncolytic Viruses as a Novel Form of Immunotherapy for Cancer)
PDF [413 KB, uploaded 7 July 2016]


Cancer therapy remains a challenge due to toxicity limitations of chemotherapy and radiation therapy. Oncolytic viruses that selectively replicate and destroy cancer cells are of increasing interest. In addition to direct cell lysis, these vectors stimulate an anti-tumor immune response. A key regulator of tumor immunity is the tumor-associated macrophage population. Macrophages can either support oncolytic virus therapy through pro-inflammatory stimulation of the anti-tumor response at the cost of hindering direct oncolysis or through immunosuppressive protection of virus replication at the cost of hindering the anti-tumor immune response. Despite similarities in macrophage interaction between adult and pediatric tumors and the abundance of research supporting macrophage modulation in adult tumors, there are few studies investigating macrophage modulation in pediatric cancers or modulation of immunotherapy. We review the current state of knowledge regarding macrophages in cancers and their influence on oncolytic virotherapy. View Full-Text
Keywords: oncolytic virus; macrophage; carcinoma; neuroblastoma; sarcoma oncolytic virus; macrophage; carcinoma; neuroblastoma; sarcoma

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Denton, N.L.; Chen, C.-Y.; Scott, T.R.; Cripe, T.P. Tumor-Associated Macrophages in Oncolytic Virotherapy: Friend or Foe? Biomedicines 2016, 4, 13.

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