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Prospects for Foamy Viral Vector Anti-HIV Gene Therapy

Pharmaceutical Sciences, College of Pharmacy, Washington State University Spokane, Spokane, WA 99202, USA
School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA
Author to whom correspondence should be addressed.
Academic Editor: Kenneth Cornetta
Biomedicines 2016, 4(2), 8;
Received: 29 January 2016 / Revised: 18 March 2016 / Accepted: 23 March 2016 / Published: 29 March 2016
(This article belongs to the Special Issue Gene Therapy Strategies for HIV/AIDS)
Stem cell gene therapy approaches for Human Immunodeficiency Virus (HIV) infection have been explored in clinical trials and several anti-HIV genes delivered by retroviral vectors were shown to block HIV replication. However, gammaretroviral and lentiviral based retroviral vectors have limitations for delivery of anti-HIV genes into hematopoietic stem cells (HSC). Foamy virus vectors have several advantages including efficient delivery of transgenes into HSC in large animal models, and a potentially safer integration profile. This review focuses on novel anti-HIV transgenes and the potential of foamy virus vectors for HSC gene therapy of HIV. View Full-Text
Keywords: gene therapy; retroviral vector; foamy viruses; anti-HIV transgenes gene therapy; retroviral vector; foamy viruses; anti-HIV transgenes
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MDPI and ACS Style

Nalla, A.K.; Trobridge, G.D. Prospects for Foamy Viral Vector Anti-HIV Gene Therapy. Biomedicines 2016, 4, 8.

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