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Biomedicines
Volume 14
Issue 5
10.3390/biomedicines14051125
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Aquaporin-4 and MicroRNA Expression in Meningiomas: A Tissue-Level Exploratory Analysis

by
Huseyin Omer Keskin
1,
Emre Ozkara
1,*,
Ebru Erzurumluoglu
2,
Zuhtu Ozbek
1,
Evrim Yilmaz
3,
Funda Canaz
3,
Didem Arslantas
4,
Sevilhan Artan
2 and
Ali Arslantas
1
1
Department of Neurosurgery, Faculty of Medicine, Eskisehir Osmangazi University, 26000 Eskisehir, Turkey
2
Department of Genetics, Faculty of Medicine, Eskisehir Osmangazi University, 26000 Eskisehir, Turkey
3
Department of Pathology, Faculty of Medicine, Eskisehir Osmangazi University, 26000 Eskisehir, Turkey
4
Department of Public Health, Faculty of Medicine, Eskisehir Osmangazi University, 26000 Eskisehir, Turkey
*
Author to whom correspondence should be addressed.
Biomedicines 2026, 14(5), 1125; https://doi.org/10.3390/biomedicines14051125
Submission received: 24 March 2026 / Revised: 29 April 2026 / Accepted: 9 May 2026 / Published: 15 May 2026
(This article belongs to the Section Cell Biology and Pathology)
Versions Notes

Abstract

Background: Meningiomas exhibit considerable biological heterogeneity that is not fully captured by histopathological grading. Tissue-based molecular markers may provide complementary insight into tumor biology within routine diagnostic settings. Methods: Formalin-fixed paraffin-embedded tissue samples from 65 intracranial meningiomas and 13 non-neoplastic controls were analyzed. Aquaporin-4 (AQP4) expression was assessed using immunohistochemistry, while miR-216a, miR-320a, and LINC00461 levels were quantified by means of RT-qPCR. Expression patterns were compared across groups and evaluated in relation to histological grade. Results: AQP4 expression was significantly reduced in meningiomas compared with controls and showed a further decrease in higher-grade tumors. Although expression of miR-216a and miR-320a was also lower in tumor samples, these differences did not reach statistical significance. Correlation analysis revealed modest but significant associations between AQP4 and miR-216a, as well as between miR-216a and miR-320a. Individual markers demonstrated limited discriminatory performance; however, combined expression patterns suggested underlying molecular variability across tumor grades. Conclusions: Our findings indicate that AQP4 downregulation represents a consistent feature in meningiomas, while associated microRNA alterations may reflect coordinated but context-dependent expression patterns. Although these markers are not sufficient as standalone diagnostic tools, their combined tissue-level assessment may provide complementary information on tumor heterogeneity. These findings should be interpreted as exploratory and highlight the need for further validation in larger and mechanistic studies.
Keywords: meningioma; aquaporin-4; microRNA; miR-216a; miR-320a; LINC00461; molecular pathology; tumor heterogeneity meningioma; aquaporin-4; microRNA; miR-216a; miR-320a; LINC00461; molecular pathology; tumor heterogeneity

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MDPI and ACS Style

Keskin, H.O.; Ozkara, E.; Erzurumluoglu, E.; Ozbek, Z.; Yilmaz, E.; Canaz, F.; Arslantas, D.; Artan, S.; Arslantas, A. Aquaporin-4 and MicroRNA Expression in Meningiomas: A Tissue-Level Exploratory Analysis. Biomedicines 2026, 14, 1125. https://doi.org/10.3390/biomedicines14051125

AMA Style

Keskin HO, Ozkara E, Erzurumluoglu E, Ozbek Z, Yilmaz E, Canaz F, Arslantas D, Artan S, Arslantas A. Aquaporin-4 and MicroRNA Expression in Meningiomas: A Tissue-Level Exploratory Analysis. Biomedicines. 2026; 14(5):1125. https://doi.org/10.3390/biomedicines14051125

Chicago/Turabian Style

Keskin, Huseyin Omer, Emre Ozkara, Ebru Erzurumluoglu, Zuhtu Ozbek, Evrim Yilmaz, Funda Canaz, Didem Arslantas, Sevilhan Artan, and Ali Arslantas. 2026. "Aquaporin-4 and MicroRNA Expression in Meningiomas: A Tissue-Level Exploratory Analysis" Biomedicines 14, no. 5: 1125. https://doi.org/10.3390/biomedicines14051125

APA Style

Keskin, H. O., Ozkara, E., Erzurumluoglu, E., Ozbek, Z., Yilmaz, E., Canaz, F., Arslantas, D., Artan, S., & Arslantas, A. (2026). Aquaporin-4 and MicroRNA Expression in Meningiomas: A Tissue-Level Exploratory Analysis. Biomedicines, 14(5), 1125. https://doi.org/10.3390/biomedicines14051125

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