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Review

The Involvement of Endothelin-1 in Sepsis and Organ Dysfunction—A Novel Biomarker in Patient Assessment

by
Cristian Sorin Prepeliuc
1,2,
Maria Antoanela Pasăre
1,3,
Maria Gabriela Grigoriu
1,3,
Ionela Larisa Miftode
3,4,*,
Radu Ștefan Miftode
5,6,
Andrei Vâță
3,4,
Irina Iuliana Costache-Enache
5,6 and
Egidia Gabriela Miftode
3,4
1
Doctoral School, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
2
County Emergency Hospital “Mavromati”, 710221 Botoșani, Romania
3
“Sf. Parascheva” Clinical Hospital of Infectious Diseases, 700116 Iași, Romania
4
Department of Infectious Diseases, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
5
Department of Internal Medicine I (Cardiology), Faculty of Medicine, University of Medicine and Pharmacy “Gr. T. Popa”, 700115 Iasi, Romania
6
Department of Cardiology, Clinical Emergency Hospital “Sf. Spiridon”, 700111 Iasi, Romania
*
Author to whom correspondence should be addressed.
Biomedicines 2025, 13(10), 2480; https://doi.org/10.3390/biomedicines13102480 (registering DOI)
Submission received: 3 September 2025 / Revised: 8 October 2025 / Accepted: 10 October 2025 / Published: 11 October 2025

Abstract

Sepsis represents a life-threatening organ dysfunction caused by a dysregulated host response to infection, and is considered a medical emergency. Therefore, quick diagnosis and treatment are required in order to improve survivability. Currently, patient evaluation in sepsis is based on the Sequential Organ Failure Assessment (SOFA) score to determine the severity of the disease; however, novel biomarkers are also actively researched with the aim to develop quicker diagnostic tools and better therapy. Endothelin-1 is one of the most potent vasoconstrictors found in the human body and is involved in the pathophysiology of both sepsis and other conditions involving organs that make up the SOFA score. In this narrative review, we aimed to gather information of this peptide’s multiple effects and to help determine whether or not it could prove a valuable biomarker in the evaluation of patients with multi-organ dysfunction in sepsis.
Keywords: sepsis; endothelin-1; biomarker; endothelin receptor; multi-organ dysfunction; cardiovascular dysfunction; renal dysfunction; liver dysfunction; pulmonary dysfunction; neurological diseases sepsis; endothelin-1; biomarker; endothelin receptor; multi-organ dysfunction; cardiovascular dysfunction; renal dysfunction; liver dysfunction; pulmonary dysfunction; neurological diseases

Share and Cite

MDPI and ACS Style

Prepeliuc, C.S.; Pasăre, M.A.; Grigoriu, M.G.; Miftode, I.L.; Miftode, R.Ș.; Vâță, A.; Costache-Enache, I.I.; Miftode, E.G. The Involvement of Endothelin-1 in Sepsis and Organ Dysfunction—A Novel Biomarker in Patient Assessment. Biomedicines 2025, 13, 2480. https://doi.org/10.3390/biomedicines13102480

AMA Style

Prepeliuc CS, Pasăre MA, Grigoriu MG, Miftode IL, Miftode RȘ, Vâță A, Costache-Enache II, Miftode EG. The Involvement of Endothelin-1 in Sepsis and Organ Dysfunction—A Novel Biomarker in Patient Assessment. Biomedicines. 2025; 13(10):2480. https://doi.org/10.3390/biomedicines13102480

Chicago/Turabian Style

Prepeliuc, Cristian Sorin, Maria Antoanela Pasăre, Maria Gabriela Grigoriu, Ionela Larisa Miftode, Radu Ștefan Miftode, Andrei Vâță, Irina Iuliana Costache-Enache, and Egidia Gabriela Miftode. 2025. "The Involvement of Endothelin-1 in Sepsis and Organ Dysfunction—A Novel Biomarker in Patient Assessment" Biomedicines 13, no. 10: 2480. https://doi.org/10.3390/biomedicines13102480

APA Style

Prepeliuc, C. S., Pasăre, M. A., Grigoriu, M. G., Miftode, I. L., Miftode, R. Ș., Vâță, A., Costache-Enache, I. I., & Miftode, E. G. (2025). The Involvement of Endothelin-1 in Sepsis and Organ Dysfunction—A Novel Biomarker in Patient Assessment. Biomedicines, 13(10), 2480. https://doi.org/10.3390/biomedicines13102480

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