Next Article in Journal
Patients with Taste Disorders in a Hospital’s Dental Department and Strategies for Taste Disorders
Next Article in Special Issue
Somatostatin Receptor Type 2 as a Potential Marker of Local Myocardial Inflammation in Myocardial Infarction: Morphologic Data on Distribution in Infarcted and Normal Human Myocardium
Previous Article in Journal
Revolutionizing Cancer Treatment: Recent Advances in Immunotherapy
Previous Article in Special Issue
Low Levels of Adropin Predict Adverse Clinical Outcomes in Outpatients with Newly Diagnosed Prediabetes after Acute Myocardial Infarction
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomedicines
Volume 12
Issue 9
10.3390/biomedicines12092159
biomedicines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

The Relationship between Lipoprotein A and the Prevalence of Multivessel Coronary Artery Disease in Young Patients with Acute Myocardial Infarction: An Observational Study

by
Ionut Cezar Buciu
1,
Eugen Nicolae Tieranu
2,3,
Andreea Stefania Pircalabu
4,
Ovidiu Mircea Zlatian
5,6,
Ionut Donoiu
2,3,
Constantin Militaru
2,3,7,
Sebastian Militaru
2,3,7,* and
Cristian Militaru
2,3,7
1
Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
2
Department of Cardiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
3
Department of Cardiology, Craiova Emergency Clinical County Hospital, 200642 Craiova, Romania
4
Department of Oncology, Craiova Emergency Clinical County Hospital, 200642 Craiova, Romania
5
Department of Microbiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
6
Medical Laboratory, Craiova Emergency Clinical County Hospital, 200642 Craiova, Romania
7
Cardiomed Hospital, 200032 Craiova, Romania
*
Author to whom correspondence should be addressed.
Biomedicines 2024, 12(9), 2159; https://doi.org/10.3390/biomedicines12092159
Submission received: 27 August 2024 / Revised: 16 September 2024 / Accepted: 20 September 2024 / Published: 23 September 2024
(This article belongs to the Special Issue Molecular Insights into Myocardial Infarction)
Browse Figures
Versions Notes

Abstract

Introduction: Cardiovascular diseases are the leading cause of mortality worldwide, with a significant impact on socioeconomic aspects. Various biomarkers have been studied in relation to the diagnosis, progression, and prognosis of atherosclerotic disease, with lipoprotein (a) [Lp (a)] standing out as an important predictor of cardiovascular risk. This observational study aimed to clarify the association between Lp (a) levels and the severity of significant multivessel coronary lesions in acute myocardial infarction (AMI) patients. Materials and Methods: Conducted at the Clinical Emergency County Hospital of Craiova, Romania, the study involved 256 young patients divided into two groups based on Lp (a) levels: Group A (Lp (a) < 30 mg/dL) and Group B (Lp (a) ≥ 30 mg/dL). Patients included young adults up to 55 years for males and 60 years for females, excluding those with familial hypercholesterolemia. Results: The study revealed a significant association between elevated Lp (a) levels and the presence of multivessel coronary lesions. Patients with Lp (a) concentrations ≥ 30 mg/dL exhibited a higher prevalence of multivessel disease compared to those with lower levels. Discussion: The findings suggest that elevated Lp (a) levels are a crucial biomarker for the risk of coronary artery disease, particularly in young patients with AMI. The study emphasizes the need for aggressive lipid management strategies and personalized treatment approaches, considering the significant role of Lp (a) in atherosclerosis and AMI. Conclusions: Lipoprotein A levels above 30 mg/dL are associated with a higher prevalence of multivessel coronary lesions. Multivariate analysis revealed that higher Lp (a) levels and lower HDL levels are linked to an increased risk of multivessel coronary lesions.
Keywords: lipoprotein A; myocardial infarction; coronary lesions; cardiovascular disease; cardiovascular risk lipoprotein A; myocardial infarction; coronary lesions; cardiovascular disease; cardiovascular risk

Share and Cite

MDPI and ACS Style

Buciu, I.C.; Tieranu, E.N.; Pircalabu, A.S.; Zlatian, O.M.; Donoiu, I.; Militaru, C.; Militaru, S.; Militaru, C. The Relationship between Lipoprotein A and the Prevalence of Multivessel Coronary Artery Disease in Young Patients with Acute Myocardial Infarction: An Observational Study. Biomedicines 2024, 12, 2159. https://doi.org/10.3390/biomedicines12092159

AMA Style

Buciu IC, Tieranu EN, Pircalabu AS, Zlatian OM, Donoiu I, Militaru C, Militaru S, Militaru C. The Relationship between Lipoprotein A and the Prevalence of Multivessel Coronary Artery Disease in Young Patients with Acute Myocardial Infarction: An Observational Study. Biomedicines. 2024; 12(9):2159. https://doi.org/10.3390/biomedicines12092159

Chicago/Turabian Style

Buciu, Ionut Cezar, Eugen Nicolae Tieranu, Andreea Stefania Pircalabu, Ovidiu Mircea Zlatian, Ionut Donoiu, Constantin Militaru, Sebastian Militaru, and Cristian Militaru. 2024. "The Relationship between Lipoprotein A and the Prevalence of Multivessel Coronary Artery Disease in Young Patients with Acute Myocardial Infarction: An Observational Study" Biomedicines 12, no. 9: 2159. https://doi.org/10.3390/biomedicines12092159

APA Style

Buciu, I. C., Tieranu, E. N., Pircalabu, A. S., Zlatian, O. M., Donoiu, I., Militaru, C., Militaru, S., & Militaru, C. (2024). The Relationship between Lipoprotein A and the Prevalence of Multivessel Coronary Artery Disease in Young Patients with Acute Myocardial Infarction: An Observational Study. Biomedicines, 12(9), 2159. https://doi.org/10.3390/biomedicines12092159

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop