Next Article in Journal
Nearly Half of Patients with Anaplastic Thyroid Cancer May Be Amenable to Immunotherapy
Previous Article in Journal
Liver Transplantation for Hepatocarcinoma: Results over Two Decades of a Transplantation Programme and Analysis of Factors Associated with Recurrence
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomedicines
Volume 12
Issue 6
10.3390/biomedicines12061303
biomedicines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Immune-Mediated Ocular Surface Disease in Diabetes Mellitus—Clinical Perspectives and Treatment: A Narrative Review

by
Laura Andreea Ghenciu
1,
Ovidiu Alin Hațegan
2,*,
Sorin Lucian Bolintineanu
3,
Alexandra-Ioana Dănilă
3,
Alexandra Corina Faur
3,
Cătălin Prodan-Bărbulescu
3,4,5,
Emil Robert Stoicescu
6,7,8,
Roxana Iacob
3,4,6 and
Alina Maria Șișu
3
1
Department of Functional Sciences, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania
2
Discipline of Anatomy and Embriology, Medicine Faculty, ‘Vasile Goldis’ Western University of Arad, Revolution Boulevard 94, 310025 Arad, Romania
3
Department of Anatomy and Embriology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania
4
Doctoral School, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania
5
IInd Surgery Clinic, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania
6
Field of Applied Engineering Sciences, Specialization Statistical Methods and Techniques in Health and Clinical Research, Faculty of Mechanics, ‘Politehnica’ University Timisoara, Mihai Viteazul Boulevard No. 1, 300222 Timisoara, Romania
7
Department of Radiology and Medical Imaging, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania
8
Research Center for Pharmaco-Toxicological Evaluations, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania
*
Author to whom correspondence should be addressed.
Biomedicines 2024, 12(6), 1303; https://doi.org/10.3390/biomedicines12061303
Submission received: 22 May 2024 / Revised: 6 June 2024 / Accepted: 10 June 2024 / Published: 12 June 2024
(This article belongs to the Special Issue Advances in Immunology for Ocular Surface Diseases and Vitreoretinal Pathologies)
Browse Figures
Review Reports Versions Notes

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder marked by hyperglycemia due to defects in insulin secretion, action, or both, with a global prevalence that has tripled in recent decades. This condition poses significant public health challenges, affecting individuals, healthcare systems, and economies worldwide. Among its numerous complications, ocular surface disease (OSD) is a significant concern, yet understanding its pathophysiology, diagnosis, and management remains challenging. This review aims to explore the epidemiology, pathophysiology, clinical manifestations, diagnostic approaches, and management strategies of diabetes-related OSD. The ocular surface, including the cornea, conjunctiva, and associated structures, is vital for maintaining eye health, with the lacrimal functional unit (LFU) playing a crucial role in tear film regulation. In DM, changes in glycosaminoglycan metabolism, collagen synthesis, oxygen consumption, and LFU dysfunction contribute to ocular complications. Persistent hyperglycemia leads to the expression of cytokines, chemokines, and cell adhesion molecules, resulting in neuropathy, tear film abnormalities, and epithelial lesions. Recent advances in molecular research and therapeutic modalities, such as gene and stem cell therapies, show promise for managing diabetic ocular complications. Future research should focus on pathogenetically oriented therapies for diabetic neuropathy and keratopathy, transitioning from animal models to clinical trials to improve patient outcomes.
Keywords: ocular surface disease; diabetic neuropathy; ocular immunology; diabetic keratopathy; limbal stem cell therapy; gene therapy ocular surface disease; diabetic neuropathy; ocular immunology; diabetic keratopathy; limbal stem cell therapy; gene therapy

Share and Cite

MDPI and ACS Style

Ghenciu, L.A.; Hațegan, O.A.; Bolintineanu, S.L.; Dănilă, A.-I.; Faur, A.C.; Prodan-Bărbulescu, C.; Stoicescu, E.R.; Iacob, R.; Șișu, A.M. Immune-Mediated Ocular Surface Disease in Diabetes Mellitus—Clinical Perspectives and Treatment: A Narrative Review. Biomedicines 2024, 12, 1303. https://doi.org/10.3390/biomedicines12061303

AMA Style

Ghenciu LA, Hațegan OA, Bolintineanu SL, Dănilă A-I, Faur AC, Prodan-Bărbulescu C, Stoicescu ER, Iacob R, Șișu AM. Immune-Mediated Ocular Surface Disease in Diabetes Mellitus—Clinical Perspectives and Treatment: A Narrative Review. Biomedicines. 2024; 12(6):1303. https://doi.org/10.3390/biomedicines12061303

Chicago/Turabian Style

Ghenciu, Laura Andreea, Ovidiu Alin Hațegan, Sorin Lucian Bolintineanu, Alexandra-Ioana Dănilă, Alexandra Corina Faur, Cătălin Prodan-Bărbulescu, Emil Robert Stoicescu, Roxana Iacob, and Alina Maria Șișu. 2024. "Immune-Mediated Ocular Surface Disease in Diabetes Mellitus—Clinical Perspectives and Treatment: A Narrative Review" Biomedicines 12, no. 6: 1303. https://doi.org/10.3390/biomedicines12061303

APA Style

Ghenciu, L. A., Hațegan, O. A., Bolintineanu, S. L., Dănilă, A.-I., Faur, A. C., Prodan-Bărbulescu, C., Stoicescu, E. R., Iacob, R., & Șișu, A. M. (2024). Immune-Mediated Ocular Surface Disease in Diabetes Mellitus—Clinical Perspectives and Treatment: A Narrative Review. Biomedicines, 12(6), 1303. https://doi.org/10.3390/biomedicines12061303

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop