Investigation of the Effect of Therapeutic Plasma Exchange for TAFRO Syndrome: A Pilot Study

Sonoda, Kosuke; Komatsu, Masamichi; Ozawa, Yoko; Yamamoto, Hiroshi; Kamijo, Yuji

doi:10.3390/biomedicines12040849

Open AccessArticle

Investigation of the Effect of Therapeutic Plasma Exchange for TAFRO Syndrome: A Pilot Study

by

Kosuke Sonoda

¹

,

Masamichi Komatsu

^2,*

,

Yoko Ozawa

²,

Hiroshi Yamamoto

^2,3 and

Yuji Kamijo

¹

Department of Nephrology, Shinshu University Hospital, Matsumoto 390-8621, Japan

²

First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto 390-8621, Japan

³

Department of Respiratory Medicine, Iida Municipal Hospital, Iida 395-8502, Japan

^*

Author to whom correspondence should be addressed.

Biomedicines 2024, 12(4), 849; https://doi.org/10.3390/biomedicines12040849

Submission received: 25 March 2024 / Revised: 9 April 2024 / Accepted: 10 April 2024 / Published: 11 April 2024

(This article belongs to the Special Issue Diagnosis, Pathogenesis and Treatment of TAFRO Syndrome)

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Abstract

TAFRO syndrome is a rare systemic inflammatory disorder with a fatal course. Nevertheless, a definitive treatment strategy has not yet been established. Anti-inflammatory therapies, including glucocorticoid treatment and immunosuppressants, have not been satisfactory. Therefore, new treatment options are needed for patients with TAFRO syndrome. The effectiveness of therapeutic plasma exchange (TPE) has mainly been reported in several case reports. In this case series study, we investigated the effect of TPE on TAFRO syndrome. We reviewed six consecutive cases with TAFRO syndrome treated at Shinshu University Hospital. All of them underwent TPE. A significant improvement in mean blood pressure, albumin, total bilirubin, and C-reactive protein was observed after TPE. Furthermore, early TPE treatment was suggested to have an impact on the prognosis. More intensive studies are needed to emphasize the overall conclusion obtained that TPE can be an effective/acceptable treatment option for TAFRO syndrome.

Keywords: TAFRO syndrome; therapeutic plasma exchange; thrombotic microangiopathy

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MDPI and ACS Style

Sonoda, K.; Komatsu, M.; Ozawa, Y.; Yamamoto, H.; Kamijo, Y. Investigation of the Effect of Therapeutic Plasma Exchange for TAFRO Syndrome: A Pilot Study. Biomedicines 2024, 12, 849. https://doi.org/10.3390/biomedicines12040849

AMA Style

Sonoda K, Komatsu M, Ozawa Y, Yamamoto H, Kamijo Y. Investigation of the Effect of Therapeutic Plasma Exchange for TAFRO Syndrome: A Pilot Study. Biomedicines. 2024; 12(4):849. https://doi.org/10.3390/biomedicines12040849

Chicago/Turabian Style

Sonoda, Kosuke, Masamichi Komatsu, Yoko Ozawa, Hiroshi Yamamoto, and Yuji Kamijo. 2024. "Investigation of the Effect of Therapeutic Plasma Exchange for TAFRO Syndrome: A Pilot Study" Biomedicines 12, no. 4: 849. https://doi.org/10.3390/biomedicines12040849

APA Style

Sonoda, K., Komatsu, M., Ozawa, Y., Yamamoto, H., & Kamijo, Y. (2024). Investigation of the Effect of Therapeutic Plasma Exchange for TAFRO Syndrome: A Pilot Study. Biomedicines, 12(4), 849. https://doi.org/10.3390/biomedicines12040849

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Investigation of the Effect of Therapeutic Plasma Exchange for TAFRO Syndrome: A Pilot Study

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