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Volume 12
Issue 2
10.3390/biomedicines12020419
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Article

Natural Killer Cells as a Further Insight into the Course of Chronic Obstructive Pulmonary Disease

by
Beata Brajer-Luftmann
1,*,
Tomasz Trafas
1,
Marta Stelmach-Mardas
2,
Weronika Bendowska
3,
Tomasz Piorunek
1,
Marcin Grabicki
1 and
Mariusz Kaczmarek
4,5
1
Department of Pulmonology, Allergology and Pulmonary Oncology, Poznan University of Medical Sciences, Szamarzewskiego 84 Street, 60-569 Poznan, Poland
2
Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Szamarzewskiego 84 Street, 61-569 Poznan, Poland
3
Department of Immunology, Poznan University of Medical Sciences, Rokietnicka 5 Street, 61-806 Poznan, Poland
4
Department of Cancer Immunology, Poznan University of Medical Sciences, Garbary 15 Street, 61-866 Poznan, Poland
5
Gene Therapy Laboratory, Department of Cancer Diagnostics and Immunology, Greater Poland Cancer Centre, Garbary 15 Street, 61-866 Poznan, Poland
*
Author to whom correspondence should be addressed.
Biomedicines 2024, 12(2), 419; https://doi.org/10.3390/biomedicines12020419
Submission received: 22 January 2024 / Revised: 6 February 2024 / Accepted: 7 February 2024 / Published: 11 February 2024
(This article belongs to the Special Issue State-of-the-Art Molecular and Translational Medicine in Poland: Volume II)
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Abstract

The role of natural killer (NK) cells in chronic obstructive pulmonary disease (COPD) pathogenesis has been discussed but is not yet clearly understood. This current study aimed to evaluate the associations between immunophenotypes, degrees of maturity, and the expression level of functional receptors of NK cells in the lung environment present in bronchoalveolar lavage fluid (BALF), and an attempt was made to determine their relationship in the course and progression of COPD. A total of 15 COPD patients and 14 healthy smokers were included. The clinical parameters of COPD were evaluated. In both groups, NK cells using monoclonal antibodies directly conjugated with fluorochromes in flow cytometry were assessed in the peripheral blood. Additionally, NK cells using the same method were assessed in BALF in the COPD subgroup. The blood’s NK cells differed from the estimated group’s maturity and receptor expression. Functional receptors CD158b+, CD314+, and CD336+ expressed by NK cells were significantly interlinked with age, RV, TLC, 6MWT, smoking, and the number of exacerbations. These results confirm the essential role of NK cells in COPD pathogenesis. Additionally, the relationship between clinical parameters and NK cell expression may indicate its participation in the disease progression and exacerbation and allow for a better understanding of NK cell biology in COPD.
Keywords: BALF; NK; COPD; immune response; pulmonary function; aging BALF; NK; COPD; immune response; pulmonary function; aging

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MDPI and ACS Style

Brajer-Luftmann, B.; Trafas, T.; Stelmach-Mardas, M.; Bendowska, W.; Piorunek, T.; Grabicki, M.; Kaczmarek, M. Natural Killer Cells as a Further Insight into the Course of Chronic Obstructive Pulmonary Disease. Biomedicines 2024, 12, 419. https://doi.org/10.3390/biomedicines12020419

AMA Style

Brajer-Luftmann B, Trafas T, Stelmach-Mardas M, Bendowska W, Piorunek T, Grabicki M, Kaczmarek M. Natural Killer Cells as a Further Insight into the Course of Chronic Obstructive Pulmonary Disease. Biomedicines. 2024; 12(2):419. https://doi.org/10.3390/biomedicines12020419

Chicago/Turabian Style

Brajer-Luftmann, Beata, Tomasz Trafas, Marta Stelmach-Mardas, Weronika Bendowska, Tomasz Piorunek, Marcin Grabicki, and Mariusz Kaczmarek. 2024. "Natural Killer Cells as a Further Insight into the Course of Chronic Obstructive Pulmonary Disease" Biomedicines 12, no. 2: 419. https://doi.org/10.3390/biomedicines12020419

APA Style

Brajer-Luftmann, B., Trafas, T., Stelmach-Mardas, M., Bendowska, W., Piorunek, T., Grabicki, M., & Kaczmarek, M. (2024). Natural Killer Cells as a Further Insight into the Course of Chronic Obstructive Pulmonary Disease. Biomedicines, 12(2), 419. https://doi.org/10.3390/biomedicines12020419

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