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Article

Microvascular and Structural Characterization of Birdshot Chorioretinitis in Active and Inactive Phases

by
Aina Moll-Udina
1,2,*,
Marina Dotti-Boada
1,
Anabel Rodríguez
1,
Maite Sainz-de-la-Maza
1,2,
Alfredo Adán
1,2 and
Victor Llorenç
1,2
1
Clinic Institute of Ophthalmology (ICOF), Clínic Hospital of Barcelona, 08028 Barcelona, Spain
2
August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Biomedicines 2024, 12(10), 2414; https://doi.org/10.3390/biomedicines12102414
Submission received: 13 September 2024 / Revised: 10 October 2024 / Accepted: 17 October 2024 / Published: 21 October 2024
(This article belongs to the Special Issue Recent Advances in Diagnosis and Therapeutic Strategies in Intraocular Inflammation)
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Abstract

Objective: This study aimed to examine microvascular changes and identify predictors of short-term quiescence in active birdshot chorioretinitis (BSCR). Methods: An observational, prospective, 12-month follow-up cohort study was conducted. BSCR eyes were clinically assessed at baseline, categorized as active or inactive, and reevaluated at 12 months. Based on their clinical activity at both timepoints, eyes were divided into three subgroups: active-to-inactive (A-I), consistently active (A-A), and consistently inactive (I-I). Structural OCT, OCT-angiography (OCT-A), and ultra-widefield imaging were utilized. Exam data from fundus and nasal subfields were analyzed for microvascular changes and quiescence predictors. Results: Sixty eyes from 30 BSCR patients (47% women, 53% men, mean age 59.7 ± 12.3 years) were included. In the A-I group (16 eyes), vascular density and perfusion indices increased in all subfields post-quiescence, contrasting with the other groups. Perifoveal looping in the superficial capillary plexus predicted quiescence at 12 months compared with the A-A group. Conclusions: Vascular density rises after complete inflammation control in BSCR, and perifoveal capillary loops serve as potential predictors of short-term quiescence in active BSCR.
Keywords: birdshot; biomarkers; chorioretinitis; imaging; non-infectious uveitis; ocular inflammation; optical coherence tomography angiography; quiescence; uveitis birdshot; biomarkers; chorioretinitis; imaging; non-infectious uveitis; ocular inflammation; optical coherence tomography angiography; quiescence; uveitis

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MDPI and ACS Style

Moll-Udina, A.; Dotti-Boada, M.; Rodríguez, A.; Sainz-de-la-Maza, M.; Adán, A.; Llorenç, V. Microvascular and Structural Characterization of Birdshot Chorioretinitis in Active and Inactive Phases. Biomedicines 2024, 12, 2414. https://doi.org/10.3390/biomedicines12102414

AMA Style

Moll-Udina A, Dotti-Boada M, Rodríguez A, Sainz-de-la-Maza M, Adán A, Llorenç V. Microvascular and Structural Characterization of Birdshot Chorioretinitis in Active and Inactive Phases. Biomedicines. 2024; 12(10):2414. https://doi.org/10.3390/biomedicines12102414

Chicago/Turabian Style

Moll-Udina, Aina, Marina Dotti-Boada, Anabel Rodríguez, Maite Sainz-de-la-Maza, Alfredo Adán, and Victor Llorenç. 2024. "Microvascular and Structural Characterization of Birdshot Chorioretinitis in Active and Inactive Phases" Biomedicines 12, no. 10: 2414. https://doi.org/10.3390/biomedicines12102414

APA Style

Moll-Udina, A., Dotti-Boada, M., Rodríguez, A., Sainz-de-la-Maza, M., Adán, A., & Llorenç, V. (2024). Microvascular and Structural Characterization of Birdshot Chorioretinitis in Active and Inactive Phases. Biomedicines, 12(10), 2414. https://doi.org/10.3390/biomedicines12102414

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