Next Article in Journal
Associations between Disc Hemorrhage and Primary Open-Angle Glaucoma Based on Genome-Wide Association and Mendelian Randomization Analyses
Next Article in Special Issue
Therapeutic Potential of Medicinal Plants and Their Phytoconstituents in Diabetes, Cancer, Infections, Cardiovascular Diseases, Inflammation and Gastrointestinal Disorders
Previous Article in Journal
Impact of Stabilization Splint Therapy on Orthodontic Diagnosis in Patients with Signs and Symptoms of Temporomandibular Disorder
Previous Article in Special Issue
Impact of Sodium Glucose Cotransporter 2 Inhibitors (SGLT2i) Therapy on Dementia and Cognitive Decline
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomedicines
Volume 12
Issue 10
10.3390/biomedicines12102252
biomedicines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Systematic Review

Dyslipidemia in Pregnancy: A Systematic Review of Molecular Alterations and Clinical Implications

by
Agnesa Preda
1,†,
Silviu-Daniel Preda
2,3,†,
Maria Mota
4,†,
Dominic Gabriel Iliescu
1,5,
Lucian George Zorila
1,5,
Alexandru Cristian Comanescu
1,5,
Adina Mitrea
6,7,*,
Diana Clenciu
6,7,
Eugen Mota
4 and
Ionela Mihaela Vladu
6,8
1
Department of Obstetrics and Gynecology, Clinical County Emergency Hospital Craiova, 200642 Craiova, Romania
2
Department of Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
3
Department of Surgery, Clinical County Emergency Hospital Craiova, 200642 Craiova, Romania
4
Doctoral School, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
5
Department of Obstetrics and Gynecology, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania
6
Department of Diabetes, Nutrition and Metabolic Diseases, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
7
Department of Diabetes, Nutrition and Metabolic Diseases, “Philanthropy” Clinical Municipal Hospital of Craiova, 200143 Craiova, Romania
8
Department of Diabetes, Nutrition and Metabolic Diseases, Clinical County Emergency Hospital Craiova, 200642 Craiova, Romania
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this paper.
Biomedicines 2024, 12(10), 2252; https://doi.org/10.3390/biomedicines12102252
Submission received: 19 August 2024 / Revised: 29 September 2024 / Accepted: 1 October 2024 / Published: 3 October 2024
(This article belongs to the Special Issue From Molecules to Medicine: Deciphering Obesity and Lipid Metabolism for Translational Insights)
Browse Figures
Versions Notes

Abstract

Background: Dyslipidemia in pregnancy presents unique clinical challenges due to its effects on maternal and fetal health. This systematic review hypothesizes that molecular alterations in lipid metabolism during pregnancy contribute to adverse pregnancy outcomes and seeks to identify the clinical implications of these changes. The rationale behind this review stems from the increased risk of complications such as preeclampsia, intrauterine growth restriction, and acute pancreatitis associated with dyslipidemia in pregnancy. The primary objective is to examine the interplay between lipid metabolism and pregnancy outcomes. Methods: To achieve this, a systematic review following PRISMA guidelines was conducted, with a comprehensive search of the PubMed database covering articles from January 2014 to June 2024. Inclusion criteria focused on studies assessing molecular alterations and clinical outcomes of dyslipidemia in pregnancy, while case reports and relevant clinical trials were analyzed to evaluate both maternal and fetal outcomes. A total of 12 studies were included in the final analysis. Results: This study provided evidence of the need for early detection and management strategies to reduce risks. The outcomes revealed significant associations between dyslipidemia and adverse maternal outcomes such as preeclampsia, gestational diabetes, and pancreatitis, as well as fetal outcomes like preterm birth and fetal distress. Conclusions: Early lipid monitoring and intervention are crucial in mitigating these risks and suggests that a multidisciplinary approach is necessary to improve maternal and fetal health in pregnancies complicated by dyslipidemia.
Keywords: dyslipidemia; fetal outcomes; maternal outcomes; molecular dyslipidemia; fetal outcomes; maternal outcomes; molecular

Share and Cite

MDPI and ACS Style

Preda, A.; Preda, S.-D.; Mota, M.; Iliescu, D.G.; Zorila, L.G.; Comanescu, A.C.; Mitrea, A.; Clenciu, D.; Mota, E.; Vladu, I.M. Dyslipidemia in Pregnancy: A Systematic Review of Molecular Alterations and Clinical Implications. Biomedicines 2024, 12, 2252. https://doi.org/10.3390/biomedicines12102252

AMA Style

Preda A, Preda S-D, Mota M, Iliescu DG, Zorila LG, Comanescu AC, Mitrea A, Clenciu D, Mota E, Vladu IM. Dyslipidemia in Pregnancy: A Systematic Review of Molecular Alterations and Clinical Implications. Biomedicines. 2024; 12(10):2252. https://doi.org/10.3390/biomedicines12102252

Chicago/Turabian Style

Preda, Agnesa, Silviu-Daniel Preda, Maria Mota, Dominic Gabriel Iliescu, Lucian George Zorila, Alexandru Cristian Comanescu, Adina Mitrea, Diana Clenciu, Eugen Mota, and Ionela Mihaela Vladu. 2024. "Dyslipidemia in Pregnancy: A Systematic Review of Molecular Alterations and Clinical Implications" Biomedicines 12, no. 10: 2252. https://doi.org/10.3390/biomedicines12102252

APA Style

Preda, A., Preda, S.-D., Mota, M., Iliescu, D. G., Zorila, L. G., Comanescu, A. C., Mitrea, A., Clenciu, D., Mota, E., & Vladu, I. M. (2024). Dyslipidemia in Pregnancy: A Systematic Review of Molecular Alterations and Clinical Implications. Biomedicines, 12(10), 2252. https://doi.org/10.3390/biomedicines12102252

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop