Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice
Abstract
:1. Introduction
2. Methods
2.1. Cell Line Culture
2.2. Animals
2.3. Drugs
2.4. Bone Marrow-Derived Macrophages
2.5. Bone Marrow-Derived MDSCs
2.6. Flow Cytometry Analysis of Immune Cells
2.7. In Vivo Tumor Models
2.8. Antigen-Specific T-Cell Response Detection by IFN-γ ELISpot
2.9. Quantitative PCR
2.10. Statistical Analysis
3. Results
4. Discussion
5. Conclusion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Alexander, E.T.; Fahey, E.; Phanstiel, O., IV; Gilmour, S.K. Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice. Biomedicines 2023, 11, 2703. https://doi.org/10.3390/biomedicines11102703
Alexander ET, Fahey E, Phanstiel O IV, Gilmour SK. Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice. Biomedicines. 2023; 11(10):2703. https://doi.org/10.3390/biomedicines11102703
Chicago/Turabian StyleAlexander, Eric T., Erin Fahey, Otto Phanstiel, IV, and Susan K. Gilmour. 2023. "Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice" Biomedicines 11, no. 10: 2703. https://doi.org/10.3390/biomedicines11102703
APA StyleAlexander, E. T., Fahey, E., Phanstiel, O., IV, & Gilmour, S. K. (2023). Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice. Biomedicines, 11(10), 2703. https://doi.org/10.3390/biomedicines11102703