Next Article in Journal
NFkB Pathway and Hodgkin Lymphoma
Previous Article in Journal
Immunotherapy in Head and Neck Cancer When, How, and Why?
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomedicines
Volume 10
Issue 9
10.3390/biomedicines10092152
biomedicines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Effectiveness and Safety of Immunosuppressants and Biological Therapy for Chronic Spontaneous Urticaria: A Network Meta-Analysis

by
Wen-Kuang Lin
1,
Shwu-Jiuan Lin
1,
Woan-Ruoh Lee
2,3,
Chia-Chieh Lin
4,
Weei-Chin Lin
5,
Hua-Ching Chang
6,7,
Chi-Tsun Cheng
8 and
Jason C. Hsu
8,9,10,11,*
1
School of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan
2
Department of Dermatology, Shuang-Ho Hospital, Taipei Medical University, New Taipei City 235041, Taiwan
3
Graduate Institute of Medical Science, School of Medicine, Taipei Medical University, Taipei 11031, Taiwan
4
Department of Pharmacy, Taipei Veterans General Hospital, Taipei 112201, Taiwan
5
Section of Hematology/Oncology, Department of Medicine and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
6
Department of Dermatology, Taipei Medical University Hospital, Taipei 110301, Taiwan
7
Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan
8
Research Center of Health Care Industry Data Science, College of Management, Taipei Medical University, Taipei 110301, Taiwan
9
International PhD Program in Biotech and Healthcare Management, College of Management, Taipei Medical University, Taipei 110301, Taiwan
10
Clinical Data Center, Office of Data Science, Taipei Medical University, Taipei 110301, Taiwan
11
Clinical Big Data Research Center, Taipei Medical University Hospital, Taipei Medical University, Taipei 110301, Taiwan
 
add Show full affiliation list
 
remove Hide full affiliation list
*
Author to whom correspondence should be addressed.
Biomedicines 2022, 10(9), 2152; https://doi.org/10.3390/biomedicines10092152
Submission received: 22 July 2022 / Revised: 14 August 2022 / Accepted: 30 August 2022 / Published: 1 September 2022
(This article belongs to the Section Immunology and Immunotherapy)
Browse Figure
Review Reports Versions Notes

Abstract

Chronic spontaneous urticaria (CSU) is the most common phenotype of chronic urticaria. We compared treatment effects and safety profiles of the medications in patients with CSU. We searched PubMed, MEDLINE, and Web of Science for randomized control trials (RCTs), from 1 January 2000 to 31 July 2021, which evaluated omalizumab and immunosuppressants. Network meta-analyses (NMAs) were performed with a frequentist approach. Outcome assessments considered the efficacy (Dermatology Life Quality Index (DLQI) and weekly urticaria activity score (UAS7)) and tolerability profiles with evaluations of study quality, inconsistencies, and heterogeneity. We identified 14 studies which we included in our direct and indirect quantitative analyses. Omalizumab demonstrated better efficacy in DLQI and UAS7 outcomes compared to a placebo, and UAS7 assessments also demonstrated better outcomes compared to cyclosporine. Alongside this, omalizumab demonstrated relatively lower incidences of safety concerns compared to the other immunosuppressants. Cyclosporin was also associated with higher odds of adverse events than other treatment options. Our findings indicate that omalizumab resulted in greater improvements in terms of the DLQI and UAS7 with good tolerability in CSU patients compared to the other immunosuppressants.
Keywords: immunosuppressant; biological therapy; chronic spontaneous urticaria; network meta-analysis; systematic review immunosuppressant; biological therapy; chronic spontaneous urticaria; network meta-analysis; systematic review

Share and Cite

MDPI and ACS Style

Lin, W.-K.; Lin, S.-J.; Lee, W.-R.; Lin, C.-C.; Lin, W.-C.; Chang, H.-C.; Cheng, C.-T.; Hsu, J.C. Effectiveness and Safety of Immunosuppressants and Biological Therapy for Chronic Spontaneous Urticaria: A Network Meta-Analysis. Biomedicines 2022, 10, 2152. https://doi.org/10.3390/biomedicines10092152

AMA Style

Lin W-K, Lin S-J, Lee W-R, Lin C-C, Lin W-C, Chang H-C, Cheng C-T, Hsu JC. Effectiveness and Safety of Immunosuppressants and Biological Therapy for Chronic Spontaneous Urticaria: A Network Meta-Analysis. Biomedicines. 2022; 10(9):2152. https://doi.org/10.3390/biomedicines10092152

Chicago/Turabian Style

Lin, Wen-Kuang, Shwu-Jiuan Lin, Woan-Ruoh Lee, Chia-Chieh Lin, Weei-Chin Lin, Hua-Ching Chang, Chi-Tsun Cheng, and Jason C. Hsu. 2022. "Effectiveness and Safety of Immunosuppressants and Biological Therapy for Chronic Spontaneous Urticaria: A Network Meta-Analysis" Biomedicines 10, no. 9: 2152. https://doi.org/10.3390/biomedicines10092152

APA Style

Lin, W.-K., Lin, S.-J., Lee, W.-R., Lin, C.-C., Lin, W.-C., Chang, H.-C., Cheng, C.-T., & Hsu, J. C. (2022). Effectiveness and Safety of Immunosuppressants and Biological Therapy for Chronic Spontaneous Urticaria: A Network Meta-Analysis. Biomedicines, 10(9), 2152. https://doi.org/10.3390/biomedicines10092152

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop