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Biomedicines
Volume 10
Issue 4
10.3390/biomedicines10040799
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Article

Assessment of the Relationship between Clinical Manifestation and Pathogenic Potential of Streptococcus pyogenes Strains-Distribution of Genes and Genotypes of Toxins

by
Tomasz Bogiel
1,*,
Alicja Domian
1,
Zuzanna Dobrzyńska
1,2,
Agnieszka Mikucka
1 and
Eugenia Gospodarek-Komkowska
1
1
Microbiology Department, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 9 M. Sklodowska-Curie Street, 85-094 Bydgoszcz, Poland
2
ALAB Laboratories Ltd., Based in Warsaw, 22/30 Stepinska Street, 00-739 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Biomedicines 2022, 10(4), 799; https://doi.org/10.3390/biomedicines10040799
Submission received: 4 February 2022 / Revised: 20 March 2022 / Accepted: 25 March 2022 / Published: 29 March 2022
(This article belongs to the Topic Infectious Diseases)
Versions Notes

Abstract

Streptococcus pyogenes is one of the most important species among beta-haemolytic streptococci, causing human infections of different localization. It is isolated from clinical specimens relatively frequently. In this study, the frequency and co-occurrence of toxin genes (speA, speB, speC, speH, speJ, speK) among 147 S. pyogenes strains were evaluated, using real-time PCR. In addition, the relationship between the occurrence of these genes and the origin of S. pyogenes strains from selected clinical material was assessed. The speB gene was present with the highest incidence (98.6%), while the speK gene was the least frequent (8.2%) among the tested strains. Based on the presence of the detected genes, the distribution of 17 genotypes was determined. The most common (21.8%), was speA (−) speB (+) speC (−) speH (−) speJ (−) speK (−) genotype. Furthermore, significant variation in the presence of some genes and genotypes of toxins in S. pyogenes strains isolated from different types of clinical material was found. There is a considerable variety and disproportion between the frequency of individual genes and genotypes of toxins in S. pyogenes strains. The relationship between the origin of S. pyogenes isolates and the presence of toxins genes indicates their pathogenic potential in the development of infections of selected localization.
Keywords: exotoxins; pyrogenic exotoxins; speA; speB; speC; speH; speJ; speK; Streptococcus pyogenes; toxins; virulence; virulence factors; virulence factors genes exotoxins; pyrogenic exotoxins; speA; speB; speC; speH; speJ; speK; Streptococcus pyogenes; toxins; virulence; virulence factors; virulence factors genes

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MDPI and ACS Style

Bogiel, T.; Domian, A.; Dobrzyńska, Z.; Mikucka, A.; Gospodarek-Komkowska, E. Assessment of the Relationship between Clinical Manifestation and Pathogenic Potential of Streptococcus pyogenes Strains-Distribution of Genes and Genotypes of Toxins. Biomedicines 2022, 10, 799. https://doi.org/10.3390/biomedicines10040799

AMA Style

Bogiel T, Domian A, Dobrzyńska Z, Mikucka A, Gospodarek-Komkowska E. Assessment of the Relationship between Clinical Manifestation and Pathogenic Potential of Streptococcus pyogenes Strains-Distribution of Genes and Genotypes of Toxins. Biomedicines. 2022; 10(4):799. https://doi.org/10.3390/biomedicines10040799

Chicago/Turabian Style

Bogiel, Tomasz, Alicja Domian, Zuzanna Dobrzyńska, Agnieszka Mikucka, and Eugenia Gospodarek-Komkowska. 2022. "Assessment of the Relationship between Clinical Manifestation and Pathogenic Potential of Streptococcus pyogenes Strains-Distribution of Genes and Genotypes of Toxins" Biomedicines 10, no. 4: 799. https://doi.org/10.3390/biomedicines10040799

APA Style

Bogiel, T., Domian, A., Dobrzyńska, Z., Mikucka, A., & Gospodarek-Komkowska, E. (2022). Assessment of the Relationship between Clinical Manifestation and Pathogenic Potential of Streptococcus pyogenes Strains-Distribution of Genes and Genotypes of Toxins. Biomedicines, 10(4), 799. https://doi.org/10.3390/biomedicines10040799

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