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Article

Cardiac Hypertrophy May Be a Risk Factor for the Development and Severity of Glaucoma

1
Department of Ophthalmology, Japan Community Health Care Organization, Mishima General Hospital, Shizuoka 411-0801, Japan
2
Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan
3
Jiyugaoka Kiyosawa Eye Clinic, Tokyo 152-0035, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Frederic Michon and Paolo Boffano
Biomedicines 2022, 10(3), 677; https://doi.org/10.3390/biomedicines10030677
Received: 23 January 2022 / Revised: 9 March 2022 / Accepted: 13 March 2022 / Published: 15 March 2022
(This article belongs to the Special Issue Regenerative Ophthalmology: From Molecular Basis to Therapy)
The purpose of this study was to examine the relationship between glaucoma and cardiac abnormalities. We evaluated 581 patients with open-angle glaucoma (285 men and 296 women) and 595 individuals without glaucoma (273 men and 322 women). All of the participants underwent visual field testing using a Humphrey Visual Field Analyzer (30-2 program), an electrocardiogram (ECG), and blood pressure measurement. We examined the ECG abnormalities and other factors (age, intraocular pressure (IOP) and systemic hypertension) involved in the development and severity of glaucoma. Logistic regression analyses revealed significant correlations of glaucoma with IOP (OR = 1.43; 95% CI: 1.36–1.51; p < 0.00001), atrial fibrillation (OR = 2.02; 95% CI: 1.01–4.04; p = 0.04), left ventricular hypertrophy (LVH) (OR = 2.21; 95% CI: 1.15–4.25; p = 0.02), and bradycardia (OR = 2.19; 95% CI: 1.25–4.70; p = 0.02). Regression analyses revealed significant correlations of the mean deviation of the visual field with age (t = –6.22; 95% CI: −0.15, −0.08; p < 0.00001), IOP (t = −6.47; 95% CI: −0.42, −0.23; p < 0.00001), and LVH (t = −2.15; 95% CI: −3.36, −0.29; p = 0.02). Atrial fibrillation, LVH and bradycardia may decrease the cerebral blood flow, and may also affect the ocular blood flow. Cardiac abnormalities may be associated with the development and severity of glaucoma. View Full-Text
Keywords: bradycardia; electrocardiogram; glaucoma; left ventricular hypertrophy; visual field bradycardia; electrocardiogram; glaucoma; left ventricular hypertrophy; visual field
MDPI and ACS Style

Suzuki, Y.; Kiyosawa, M. Cardiac Hypertrophy May Be a Risk Factor for the Development and Severity of Glaucoma. Biomedicines 2022, 10, 677. https://doi.org/10.3390/biomedicines10030677

AMA Style

Suzuki Y, Kiyosawa M. Cardiac Hypertrophy May Be a Risk Factor for the Development and Severity of Glaucoma. Biomedicines. 2022; 10(3):677. https://doi.org/10.3390/biomedicines10030677

Chicago/Turabian Style

Suzuki, Yukihisa, and Motohiro Kiyosawa. 2022. "Cardiac Hypertrophy May Be a Risk Factor for the Development and Severity of Glaucoma" Biomedicines 10, no. 3: 677. https://doi.org/10.3390/biomedicines10030677

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